The Focus of the Study is to Monitor MRI Signal Changes and Inflammatory Biomarkers With Use of Aspirin in Patients With Unruptured Cerebral Aneurysm

aspirin

University of Iowa hospitals and Clinics

Aspirin Attenuates Inflammation in Human Cerebral Aneurysms

Aspirin as a Promising Agent to Attenuate Inflammation in the Wall of Human Cerebral Aneurysms

At the end of treatment, Inflammatory biomarkers are used to assess the efficacy of treatment (aspirin)

at the end of the 3 months, the MRI signal intensity are measured and compared to the baseline

David Hasan

Assistant Professor and Section Chief

University of Iowa

Postoperative Quality of Recovery

Postoperative Migrainous Headache

Single subcutaneous injection sumatriptan 6mg (in 0.5ml) in recovery

Sumatriptan

Single injection saline 0.5ml subcutaneously in recovery

Placebo

Toronto Western Hospital

Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy

Using the validated Quality of Recovery 40 Questionnaire (QoR-40)

Lashmi Venkatraghavan

University Health Network, Toronto

The patients in the control arm will receive sham nerve blocks with 20 ml of saline + epinephrine 1:200,000, in a manner identical to that described for the treatment group.

The patients in the intervention group will receive bilateral scalp nerve blocks with a total of 20 ml of 0.5% bupivacaine + epinephrine 1:200,000.

Supratentorial Neoplasms

Aneurysms

Arteriovenous Malformation

Epilepsy

Scalp nerve blocks will be performed bilaterally at the end of the surgery under general anaesthesia and before removal of the head holder. Patients will receive scalp nerve blocks with a total of 20 ml of 0.5% bupivacaine + epinephrine 1:200,000 or 20 ml of saline + epinephrine 1:200,000. Solution volume is as follows: 2ml each bilaterally for supraorbital and supratrochlear nerves; 3 ml for the auriculotemporal nerves; 2 ml for the postauricular branches of the greater auricular nerves and for the greater, lesser, and third occipital nerves 3 ml of solution will be infiltrated along the superior nuchal line, approximately halfway between the occipital protuberance and the mastoid process.

Bilateral Scalp Nerve Blocks

St. Michael's Hospital

Scalp Nerve Blocks for Post-Craniotomy Pain

Effect of Bilateral Scalp Nerve Blocks on Post-operative Pain and Discharge Times in Patients Undergoing Supra-tentorial Craniotomy and General Anaesthesia

intracranial aneurysm/nàusea

Aspirin Attenuates Inflammation in Human Cerebral Aneurysms

Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy

Scalp Nerve Blocks for Post-Craniotomy Pain

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