Neonatal SEPSIS

score for neonatal sepsis to predict morbidity

score for neonatal sepsis

Faculty Of medicine Cairo University

Severity Index of Neonatal Septicemia Using Score for Neonatal Acute Physiology (SNAP) II

Severity Index of Neonatal Septicemia of Cases Admitted at Neonatal Intensive Care Units at CHILDREN'S HOSPITAL, CAIRO UNIVERSITY and at ELGALAA Children's MILITARY HOSPITAL Using Score for Neonatal Acute Physiology (SNAP) II

Ahmed Mahmoud Ali Ali Youssef

Doctor

Nitazoxanide dosing: 500 mg tablets twice daily
Lactulose dosing: 30-60 mL PO TID with goal 2-3 semisoft stools per day

Lactulose dosing: 30-60 mL PO TID with goal 2-3 semisoft stools per day

Encephalopathy, Hepatic

• Nitazoxanide dosing: 500 mg tablets twice daily

Nitazoxanide

• Lactulose dosing: 30-60 mL PO TID with goal 2-3 semisoft stools per day

Lactulose

Tanta university - faculty of medicine

Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy

A Randomized, Double-blind, Controlled Trial Comparing Nitazoxanide Plus Lactulose With Lactulose Alone Treatment of Overt Hepatic Encephalopathy

Sherief Abd-Elsalam

sponsor investigator

Tanta University

Patients with epilepsy recorded in an inpatient video-EEG monitoring unit after a seizure.

Epilepsy Inpatients

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Region of Enrollment

The investigators will assess the salivary lactic acid within 10 minutes after end of a seizure. Values will consist of lactic acid measurements in saliva , immediately post-seizure. Units of measurement will be mM/L. A positive outcome will be a curve different from a straight line, with a rise and fall of lactate levels. Baseline lactate serum level is expected to be less than 2.2 mM/L.

Salivary Lactic Acid Levels With Seizures

The investigators will assess the capillary lactic acid within 10 minutes after end of a seizure. Values will consist of lactic acid measurements in blood, within 10 minutes after the end of a seizure. Units of measurement will be mM/L. Baseline lactate serum level is expected to be less than 2.2 mM/L.

Capillary Lactic Acid Levels With Seizures

The investigators will assess the intravenous lactic acid within 10 minutes after end of a seizure. Values will consist of lactic acid measurements in serum collected by IV, immediately post-seizure. Units of measurement will be mM/L. A positive outcome will be a curve different from a straight line, with a rise and fall of lactate levels. Baseline lactate serum level is expected to be less than 2.2 mM/L.

Intravenous Lactic Acid Levels With Seizures

Salivary levels of lactic acid is being studied because saliva is more accessible in the outpatient setting than is blood. Concentration of lactic acid in the serum and saliva from each individual subject will be correlated using Pearson's correlation test. We will consider a positive outcome to be a r greater than or equal to 0.5 and significance at p<0.05.

Salivary and Capillary Lactic Acid Will be Correlated After a Seizure

Patients who have blood or salivary (or both) levels recorded after a seizure.

Overall Study

Robert S. Fisher, MD, PhD

Epilepsy

Stanford Hospital

Lactic Acidosis During and After Seizures

If subjects wish to know their lactic acid levels after a seizure, we will provide the information, although it currently has no therapeutic or prognostic implications.

lactic acid/seizures

Severity Index of Neonatal Septicemia Using Score for Neonatal Acute Physiology (SNAP) II

Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy

Lactic Acidosis During and After Seizures

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