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Lysergic acid diethylamide causes photoreceptor cell damage through inducing inflammatory response and oxidative stress.

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Lysergic acid diethylamide (LSD), a classical hallucinogen, was used as a popular and notorious substance of abuse in various parts of the world. Its abuse could result in long-lasting abnormalities in retina and little is known about the exact mechanism. This study was to investigate the effect of

Effects of lysergic acid diethylamide (LSD) and adjuvant-induced inflammation on desensitization to and metabolism of substance P in the mouse spinal cord.

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We have previously shown that the caudally directed biting and scratching response to repeated intrathecal (i.t.) injections of substance P (SP) is decreased by the third injection of SP and that this apparent desensitization to SP is less pronounced in mice pretreated with Freund's adjuvant. This

Long-term systemic treatment with lysergic acid diethylamide causes retinal damage in CD1 mice.

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As a classical hallucinogen with high potential for abuse, lysergic acid diethylamide (LSD) can cause long-lasting abnormalities in retina, but little is known about the exact mechanism. This study was to investigate effects of long-term systemic treatment of LSD at low dose on retinal damage and

Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers.

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Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT_2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with neurodegenerative

Serotonin-S2 receptor binding sites and functional correlates.

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Serotonin-S2 receptor binding sites have been labelled with several ligands such as [3H]spiperone, [3H]lysergic acid diethylamide (LSD), [3H]mianserin and [3H]ketanserin, the latter being the most selective ligand. The greatest concentration of the sites occurs in frontal cortical tissue, but they

Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities.

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Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant modulatory effects on immune responses by altering signaling pathways involved in inflammation, cellular proliferation, and cell survival via activating

Phytochemical investigation of natural and in vitro raised Vṛddhadāruka plants.

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BACKGROUND Argyreia nervosa commonly known as elephant creeper (English) and Vṛddhadāruka (Sanskrit) is a woody climber that belongs to the family Convolvulaceae. Seeds of this plant contain hallucinogens including ergot alkaloids and a naturally occurring lysergic acid amide. Traditionally the

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