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Pàgina 1 des de 31 resultats
[The role of melanin in regulating free radical processes in the epithelial eye pigment in acute hypoxia].
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Retinal response to the acute hypoxia and reoxygenation were shown to be independent of melanin presence in the eye pigmental epithelium (PE), i.e. in the retinas of both pigmented animals and albinos hypoxia survived an increase in the content of hydroperoxidases and malonyl dialdehyde; subsequent
[Biological properties of melanin (Pseudomonas aeruginosa)].
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Melanin synthetized by Pseudomonas aeruginosa has been found to protect these bacteria from hyper- and hypoxia, as well as from the lethal action of ultraviolet radiation. The author believes that melanin-synthetizing P. aeruginosa strains are more dangerous in hospitals than P. aeruginosa strains
Intrathecal melanin-concentrating hormone reduces sympathetic tone and blocks cardiovascular reflexes.
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Melanin-concentrating hormone (MCH) is a neuropeptide that acts to increase feeding behavior and decrease energy expenditure. The role of MCH in central cardiorespiratory regulation is still poorly understood. Experiments were conducted on urethane-anesthetized, vagotomized, and artificially
Melanin directly converts light for vertebrate metabolic use: heuristic thoughts on birds, Icarus and dark human skin.
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Pigments serve many visually obvious animal functions (e.g. hair, skin, eyes, feathers, scales). One is 'melanin', unusual in an absorption across the UV-visual spectrum which is controversial. Any polymer or macro-structure of melanin monomers is 'melanin'. Its roles derive from complex structural
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
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Evolutionary and biomedical consequences of internal melanins.
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The adaptive function of melanin located in the integument is well known. Although pigments are also deposited in various internal organs, their function is unclear. A review of the literature revealed that 'internal melanin' protects against parasites, pollutants, low temperature, oxidative stress,
An Aggressive Hypoxia Related Subpopulation of Melanoma Cells is TRP-2 Negative.
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Despite existing vaccination strategies targeting TRP-2, its function is not yet fully understood. TRP-2 is an enzyme involved in melanin biosynthesis and therefore discussed as a differentiation antigen. However, in mice Trp-2 was shown to be expressed in melanocyte stem cells of the hair follicle
Transcriptomic and virulence factors analyses of Cryptococcus neoformans hypoxia response.
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Cryptococcus neoformans is an environmental pathogen requiring atmospheric levels of oxygen for optimal growth. Upon inhalation, C. neoformans disseminates to the brain and causes meningoencephalitis. However, the mechanisms by which the pathogen adapts to the low-oxygen environment in the brain
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity.
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In response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an essential molecule required for the metabolic rewiring of macrophages during infection with the fungal pathogen
Skin SO₂ measurement using visible lightguide spectrophotometry in a black population: a feasibility study.
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The aim of the study was to investigate the influence of melanin content on the visible wavelength range spectrophotometric measurement of SO(2) in the skin of normal healthy black and white volunteers. The reactive hyperaemia induced by a 5-minute period of tourniquet occlusion of the brachial
Other PET Tracers and Prospects for the Future.
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(18)F FDG-PET has proven its use as a technique in the field of melanoma, but there are valid concerns related to the specificity of (18)F FDG-PET findings and the degree of accuracy we can expect in the assessment of response to new treatment protocols. The main avenues currently being explored for
Multisubstance analysis of reflection spectra before and after laser photocoagulation for proliferative diabetic retinopathy.
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OBJECTIVE
The aim of the study was to provide new data that add to the understanding of diabetic retinopathy and its treatment by photocoagulation.
METHODS
Using a spectrometric method, the reflection spectra of the macula in six type II diabetics with proliferative diabetic retinopathy were
Ubiquitous expression and multiple functions of biologically active peptides.
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Biologically active peptides are widely expressed throughout in human bodies. For example, endothelin-1 and adrenomedullin are expressed in almost all types of cells, including neurons, glial cells, fibroblasts, macrophages, cardiomyocytes, vascular endothelial cells, epithelial cells and cancer
Melatonin, melanogenesis, and hypoxic stress in the newt, Triturus carnifex.
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Groups of 6 specimens each of the newt Triturus carnifex were treated with melatonin to see if the hormone inhibited melanogenesis in the Kupffer cells of the liver (melanomacrophages), a process markedly stimulated by hypoxia. A dose of 500 microg/g in 27% ethanol, injected intraperitoneally,
Relationships between hepatic melanogenesis and respiratory conditions in the newt, Triturus carnifex.
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The Kupffer cells (melanomacrophages) in the livers of lower vertebrates contain varying quantities of melanin according to the season. Specimens of Triturus carnifex raised for 2 months at 6 degrees C and then transferred to water at 22 degrees C show a rapid increase in the hepatic accumulation of
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