Group (PHN) (n=15): will receive hypotensive anesthesia with phentolamine infusion (Rogitamine, Egypharma) via syringe pump by adding 20 mg (2ml) of Phentolamine to 48 ml of normal saline making it to final concentration of 0.4 mg/ml at the rate of 0.1-2 mg/min according to the patients desired target blood pressure

Group MG (n=15): will receive hypotensive anesthesia with 40 mg/kg Magnesium sulphate as bolus in 15 min with infusion later on till end of surgery at the rate of 10 mg/kg/hr .

Mean Blood Pressure

Benisuef univercity

Phentolamine Versus Magnesium Sulphate Infusion During Elective Lumbar Spine Surgery: a Randomized Double Blind Comparative Study

doaa rashwan

Assistant professor Doaa Rashwan

Beni-Suef University

29 women randomized to Belladonna & Opium suppository

27 women randomized to Glycerin suppository

29 women randomized to Belladonna & Opium suppository
Belladonna Opium: Belladonna Opium 16.2-60mg rectal suppository

Belladonna & Opium

27 women randomized to Glycerin suppository
Glycerin Suppository: Glycerine rectal suppository

Placebo

Total

Sex: Female, Male

Race and Ethnicity Not Collected

Pre-operative diagnosis of pelvic pain, dysmenorrhea, or dyspareunia

Pain-related indication for surgery

Robotic surgery

Laparoscopic surgery

Performed by a high-volume surgeon

Surgery length

Planned admission for 23-hour observation

Dexamethasone while under anesthesia

Lidocaine while under anesthesia

Ketorolac while under anesthesia

Zofran while under anesthesia

Reglan while under anesthesia

Scopolamine patch pre-operatively

Visual analog pain scale (VAS) (0 to 10, 0 = no pain, 10 = maximum pain), averaged over duration of PACU stay until discharge criteria met

Post-operative Pain: VAS

Cumulative oral and intravenous narcotics received in PACU until PACU discharge criteria met

Narcotic Use

Time elapsed from conclusion of surgery until criteria for PACU discharge met

Time Until Cleared for PACU Discharge

Binary assessment of whether anti-emetics received in PACU

Number of Participants for Which Anti-emetics Were Received in PACU

Overall Study

Anna Reinert, MD

Hysterectomy

Pain, Postoperative

Belladonna Opium 16.2-60mg rectal suppository

Belladonna Opium

Glycerin Suppository

Mercy Medical Center

B&O for TLH Post-operative Pain and Nausea

Belladonna and Opium Rectal Suppository Effect on Postoperative Pain and Nausea Following Total Laparoscopic and Robotic-Assisted Hysterectomy

Anna Reinert

Study coordinator, Resident Physician

University of Maryland, College Park

Randomization to one-time intervention A (medicated suppository) or intervention B (placebo), allocation was sealed in consecutively numbered opaque envelopes generated by biostatistician using blocked randomized technique.

Opaque sealed envelopes generated by biostatistician used to determine intervention A or B. Drug dictionary entries created within the Pyxis system by the Mercy Medical Center Department of Pharmacy, as "Protocol Drug A" and "Protocol Drug B", recorded in medical record in this way. Identity of "Protocol Drug A" and "Protocol Drug B" revealed by pharmacist at conclusion of data analysis.

30 mg mirtazepine will be given to patients on day 6 of their treatment for a period pf 3 days to observe for tolerability followed by 60 mg from day 9 of treatment until the end of the study (16 weeks).

matched placebo mirtazapine capsules will be given to patients in this group

Heroin Dependence

Amphetamine Dependence

One capsule (15 mg) oral mirtazepine daily will be started on day six of treatment for a period of 3 days followed by two capsules (30 mg) daily for a period of four months

Mirtazapine

Similar capsule containing placebo will be started on day six of treatment for a period of 3 days followed by two capsules of placebo daily for a period of four months

University Science Malaysia

Mirtazapine as a Treatment for Co-Occurring Opioid and ATS Dependence in Malaysia

Mirtazapine as a Treatment for Co-Occurring Opioid and Amphetamine Type Stimulant Dependence (COATS) in Malaysia

This will be measured from baseline over time during treatment, based on urine toxicology testing and self-report

Measured by repeated assessments of sexual and HIV risk behaviours

Measured by repeated assessments of neuropsychological functioning

Vicknasingam B Kasinather

Universiti Sains Malaysia

Yale University

Belladonna (16.2 mg) and opium (60 mg) suppositories administered rectally immediately following surgery and every 8 hours for 16 hours for a total of 3 doses.

Placebo suppositories administered rectally immediately following surgery and every 8 hours for 16 hours for a total of 3 doses.

Belladonna and Opium Suppositories

Placebo Suppositories

Region of Enrollment

Pelvic Organ Prolapse

Procedure time

Estimated Blood Loss

Pain was recorded on a validated numeric pain scale (1-10), with 0 = no pain and 10 = worst pain imaginable. Not all participants completed the pain scale, therefore the populations analyzed were Belladonna and Morphine Suppository Arm (N=39), Placebo Suppository Arm (N=45).

Preoperative Pain

Pain at 4 hours was recorded using a linear analog pain scale, with 0 being "no pain," and 10 being "worst pain imaginable."

Pain at Hour 4

Pain at 12 hours was recorded using a linear analog pain scale, with 0 being "no pain," and 10 being "worst pain imaginable."

Pain at Hour 12

Pain at 20 hours was recorded using a linear analog pain scale, with 0 being "no pain," and 10 being "worst pain imaginable."

Pain at Hour 20

Use of all ancillary narcotic medications was taken from the medical record.

Narcotic Rescue Medication

This information was taken from the medical record.

Number of Subjects With Nausea

Number of Subjects With Vomiting

Number of Times Antiemetic Rescue Medication Was Used

Number of Subjects Who Used Antiemetic Rescue Medications

Patient satisfaction with pain relief was evaluated 24 hours after surgery using a linear analog satisfaction scale, with 0 being "very dissatisfied," and 10 being "very satisfied."

opium/nàusea

Phentolamine Versus Magnesium Sulphate Infusion During Elective Lumbar Spine Surgery: a Randomized Double Blind Comparative Study

B&O for TLH Post-operative Pain and Nausea

Mirtazapine as a Treatment for Co-Occurring Opioid and ATS Dependence in Malaysia

Postoperative Belladonna and Morphine Suppositories in Vaginal Surgery

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