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osteomyelitis/protease
L'enllaç es desa al porta-retalls
Pàgina 1 des de 16 resultats
A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis.
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Osteomyelitis is a common manifestation of invasive Staphylococcus aureus infection. Pathogen-induced bone destruction limits antimicrobial penetration to the infectious focus and compromises treatment of osteomyelitis. To investigate mechanisms of S. aureus-induced bone destruction, we developed a
[Treatment of experimental osteomyelitis with dimexid, protease inhibitors and proteolytic enzymes].
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Acute osteomyelitis of the tibial bone was induced in 100 young rabbits. Four series of experiments were conducted. Treatment of osteomyelitis began from the 15th day after challenge. Antibiotics were used for the treatment of all the animals. The best results were obtained in the series where
[Protease mechanism of changes in fibrinolytic activity of blood in hematogenic osteomyelitis in children].
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Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis.
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Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease, and patients with active or recurrent bone inflammation at multiple sites are diagnosed with chronic recurrent multifocal osteomyelitis (CRMO). The Chronic multifocal osteomyelitis (CMO) mouse model develops IL-1β-driven
[The combined-action preparation Sipralinat in the treatment of suppurative diseases of the soft tissues and osteomyelitis of the bones of the foot].
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Sipralynate is a powder containing the broad spectrum antibiotic sisomicin, the enzyme protease C and the polymer carrier sodium alginate with a drainage capacity promoting wound regeneration. The clinical trials with sipralynate showed that it was highly efficient in the treatment of patients with
[Enteral detoxication using polymethylsiloxane in the comprehensive treatment of septic forms of acute hematogenous osteomyelitis in newborn babies].
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With regard for the role of bacterial and viral toxins and proteases in the pathogenesis of septic forms of acute hematogenous osteomyelitis, the use of enteral detoxication in the pediatric practice has been substantiated. The authors within 1988-1989, in 35 newborns with septic forms of acute
The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population.
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Extracellular Bacterial Proteases in Chronic Wounds: A Potential Therapeutic Target?
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Significance: Bacterial biofilms are considered to be responsible for over 80% of persistent infections, including chronic lung infections, osteomyelitis, periodontitis, endocarditis, and chronic wounds. Over 60% of chronic wounds are colonized with bacteria that reside within a biofilm. The
Exploiting correlations between protein abundance and the functional status of saeRS and sarA to identify virulence factors of potential importance in the pathogenesis of Staphylococcus aureus osteomyelitis.
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We used a murine model of post-surgical osteomyelitis (OM) to evaluate the relative virulence of the Staphylococcus aureus strain LAC and five isogenic variants that differ in the functional status of saeRS and sarA relative to each other. LAC and a variant in which saeRS activity is increased
[Immunology in the medical practice. XXVII. Mannose-binding lectin, an important link for nonspecific or hereditary immune reaction].
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In the course of the past two decennia, a 3rd route of complement activation (next to the classical and the alternative routes) has been identified: the lectin route in which mannose-binding lectin (MBL) plays an essential role. MBL is produced in the liver. From the phylogenetic and functional
The role of Pseudomonas aeruginosa in infections.
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Pseudomonas aeruginosa, an organism ubiquitous in nature, has assumed an increasingly prominent role as the aetiological agent in serious infections in hospitalized patients. Pseudomonas has a number of pathogenic properties, which include its capsule, exotoxin A and various proteases. Although
The impact of msaABCR on sarA-associated phenotypes is different in divergent clinical isolates of Staphylococcus aureus.
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The staphylococcal accessory regulator (sarA) plays an important role in Staphylococcus aureus infections including osteomyelitis, and the msaABCR operon has been implicated as an important factor in modulating expression of sarA Thus, we investigated the contribution of
Pharmacodynamics of ClpP Activating Antibiotic Combinations against Gram-Positive Pathogens.
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It is often difficult to cure endocarditis, osteomyelitis, and device-associated infections caused by Gram-positive pathogens, despite therapy with clinically appropriate antibiotics. This may be due to antibiotic tolerance or resistance development. Acyldepsipeptides are a class of bactericidal
Bacillus cereus and related species.
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Bacillus cereus is a gram-positive aerobic or facultatively anaerobic spore-forming rod. It is a cause of food poisoning, which is frequently associated with the consumption of rice-based dishes. The organism produces an emetic or diarrheal syndrome induced by an emetic toxin and enterotoxin,
Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease.
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A leucine-to-proline missense mutation at residue 98 in the proline-serine-threonine phosphatase interacting protein 2 (Pstpip2) gene leads to autoinflammatory disease that is characterized by splenomegaly, necrosis, and spontaneous development of osteomyelitis in mice (Pstpip2cmo). Disease
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