8 resultats
Thanks to a better understanding of the pathophysiological mechanisms of inflammatory rheumatism, rheumatology has known for several decades a growth in its therapeutic arsenal (csDMARDs, bDMARDs, tDMARDs). rheumatism control has thus been optimized.
however, patients very often keep pain, anxiety,
The efficacy of non-invasive VNS therapy in patients with axial SpA has never been studied. This study will assess the benefit-risk balance of the therapy through a randomized double-blind cross over clinical trial.
This multi-center study will be conducted in rheumatology departments of 17 public
The spondyloarthritides are a group of inflammatory rheumatic diseases, including ankylosing spondylitis, reactive arthritis, inflammatory bowel disease-related rheumatic disease, and psoriatic arthritis.
The frequence of axial spondyloarthritis is 0.41% in the french population. This disease is
This work will:
1. • To study for the first time the implication of the objective skeletal muscular impact in fatigue during SA.
2. • To better characterize the skeletal muscle impact of SA;
3. • To characterize the evolution of the fatigue and the muscular impact under anti-TNFα treatment and the
The study consisted of 2 treatment periods: a double-blind, placebo-controlled period from Baseline to Week 8 (Treatment Period 1) and a double-blind secukinumab treatment period from Week 8 to Week 24 (Treatment Period 2).
At Baseline (Treatment Period 1), patients were randomized in a 3:1 ratio to
Articular involvement is the most frequent extra-intestinal manifestation of inflammatory bowel diseases (IBD), frequently follows a course that is independent of the course of intestinal involvement, and its diagnosis mainly relies on clinical evidence and imaging data, because laboratory
This is a Phase 3, placebo-controlled, double-blind randomized study with an open-label phase designed to evaluate the efficacy and safety of adalimumab 40 mg administered every other week in adult patients with active axial spondyloarthritis (SpA) who are not diagnosed with ankylosing spondylitis,