Repeated fecal infusions by colonoscopy. Before FMT, vancomycin is administered in all patients for 3 days

Single fecal infusion by colonoscopy.Before FMT, vancomycin is administered in all patients for 3 days

Clostridium Difficile

Pseudomembranous Colitis

Patients will receive a single fecal infusion by colonoscopy

Single-infusion FMT

Vancomycin is administered in all patients for 3 days before randomization. Then vancomycin is stopped and patients are randomized to single-infusion FMT or multiple-infusion FMT.

Vancomycin (before randomization)

Patients will receive multiple fecal infusions by colonoscopy

multiple-infusion FMT

Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection

Randomized Clinical Trial: Single Versus Multiple-infusion Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection

Disappearance of C. difficile-associated diarrhea

Giovanni Cammarota

Associate Professor of Gastroenterology

Catholic University of the Sacred Heart

Fecal microbiota transplantation from healthy donors will be infused by colonoscopy

Standard antibiotic therapy according to European Guidelines (vancomycin and metronidazole) will be administered to the patients

Fecal Microbiota Transplantation

Standard Antibiotic Therapy

Vancomycin will be administered in all patients for 5 days before randomization. Then, patients will be randomized in FMT Group or Standard Antibiotic therapy Group. Patients in the FMT Group will stop vancomycin 24 hours before the fecal microbiota transplantation. Patients in the Standard Antibiotic Therapy Group will continue vancomycin.

Catholic University of Sacred Heart - "A. Gemelli" University Hospital

Fecal Microbiota Transplantation by Colonoscopy for Recurrent C. Difficile Infection

Fecal Microbiota Transplantation by Colonoscopy for Recurrent C. Difficile Infection: an Open-label Randomized Clinical Trial

Prof. Giovanni Cammarota

fecal microbiota transplantation
fecal microbiota transplantation

Fecal Microbiota Transplant

Sex: Female, Male

Race and Ethnicity Not Collected

Region of Enrollment

Resolution of diarrhea, time to decrease in elevated WBC count

Number of Participants With Resolution of Severe CDAD

Number of Participants with evidence of relapse of C. diff. associated diarrhea

Number of Participants With Relapse of CDAD

All Cause Mortality

Number of Participants who undergo colectomy due to CDAD

Need for Colectomy

immediate colonoscopy-related complications, secondary infection

Morbidity

Overall Study

Jacob Strahilevitz

fecal microbiota transplantation

Hadassah Medical Center

Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis

STRAHILEVITZ JACOB

Senior physician

Hadassah Medical Organization

intravenous drug user (IDU) with HIV infected

persons receiving methadone maintenance treatment

HIV Infections

Kaoshing Medical University Chung-Ho Memorial Hospital

Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison

Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison and Set up the Notional Halfway Home in Union Area of Medical Facility

syphilis/diarrea

Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection

Fecal Microbiota Transplantation by Colonoscopy for Recurrent C. Difficile Infection

Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis

Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison

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