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theophylline/obesitat
L'enllaç es desa al porta-retalls
Pàgina 1 des de 99 resultats
Theophylline clearance: effect of marked obesity.
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Total body clearance (ClT) of theophylline was examined in 12 markedly obese patients and related to total body weight (TBW) and ideal body weight (IBW). Patients were infused with aminophylline continuously and evaluated at steady state. Total body clearances of theophylline were 29.5 +/- 7.8
Pharmacokinetics of theophylline in obesity.
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Pharmacokinetic analysis of theophylline was performed in 16 obese women before and after 3-week weight-reducing treatment. Decrease of clearance, increase of t1/2, AUC, and MRT were observed. There were no differences between the volume of distribution before and after weight-reducing treatment.
Theophylline disposition in obese rats.
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A dietary-induced animal model of obesity was examined to assess the mechanisms of obesity-altered changes in theophylline clearance and distribution. Obesity was induced over several months in Sprague-Dawley rats by feeding a palatable "cafeteria" diet containing approximately 60% fat in addition
Intrasubject variability of theophylline clearance in a morbidly obese patient.
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It is well appreciated that theophylline pharmacokinetics exhibits wide intersubject variation. Within-subject changes in clearance have been generally reported in patients with acute exacerbations of disease states such as cor pulmonale or heart failure. Apparent random changes in theophylline
The effect of obesity on apparent volume of distribution of theophylline.
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An oral theophylline product was given to eight lean, normal subjects and eight obese subjects (four with asthma and four normals) in a single-dose study. The mean apparent volume of distribution (Vd) was 0.472 +/- 0.08 liters/kg for the lean group and 0.321 +/- 0.063 liters/kg for the obese group
Theophylline tissue partitioning and volume of distribution in normal and dietary-induced obese rats.
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Theophylline tissue distribution was examined in normal and dietary-induced obese Sprague-Dawley rats following constant infusion to steady-state. Theophylline distribution was linear among all tissues and uniform throughout body water spaces. The apparent distribution coefficient, Kd,app (tissue:
Theophylline clearance in obese patients in relation to smoking and congestive heart failure.
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The effect of obesity on the total body clearance (Cltot) of theophylline was evaluated in nonsmokers and smokers with and without congestive heart failure (CHF). The obese patients were compared with similar nonobese subjects with regard to age, sex, and disease state. The total patient population
Theophylline disposition in obesity.
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Theophylline disposition was examined in 14 obese subjects and 57 normal subjects. A single oral dose of aminophylline solution was given and serum and saliva samples were collected over several hours and assayed by high-pressure liquid chromatography. The apparent volume of distribution (Vd) and
Effect of ephedrine and theophylline on weight loss, resting energy expenditure and lipoprotein lipase activity in obese over-fed rats.
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The effect of ephedrine (E) and theophylline (T), administered alone and in combination (E/T), on weight loss, resting energy expenditure and post-heparin lipoprotein lipase activity in plasma (PHLA) and in adipose tissue (ATLP) were investigated in obese over-fed rats, who had been diet restricted
Effects of obesity and ancillary variables (dialysis time, drug, albumin, and fatty acid concentrations) on theophylline serum protein binding.
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The effect of obesity on the serum protein binding of theophylline was investigated in man and rat along with other ancillary variables such as dialysis time, theophylline concentration, albumin concentration, and fatty acid type and concentration. The percent binding of theophylline first increased
Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice.
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KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) has been reported to cause hepatic fat loss. However, the action mechanisms of KMUP-1 in obesity-induced steatohepatitis remains unclear. This study elucidated the steatohepatitis via matrix metallopeptidase 9 (MMP-9) and
[Importance of the association of a salidiuretic and a theophylline derivative in the treatment of obesity with respiratory insufficiency].
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[Fat cell lipolysis induced by theophylline in obese subjects before and after caloric restriction].
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Theophylline loading dose in obese patients.
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Theophylline pharmacokinetics in an extremely obese patient.
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