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Pàgina 1 des de 211 resultats
Ureas and compositions thereof for treating cancer, inflammation, or a viral infection
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1. FIELD OF THE INVENTION
The present invention relates to novel carbamates, ureas, and pharmaceutically acceptable salts thereof; compositions comprising the carbamate, urea, or a pharmaceutically acceptable salt thereof; and methods for treating or preventing cancer, inflammation, or a viral
1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b- ]pyrazin-8-yl)oxy]phenyl]urea derivatives as RAF inhibitors for the treatment of cancer
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RELATED APPLICATION
This application is related to: United Kingdom patent application number 1320729.5 filed 25 Nov. 2013, the contents of which are incorporated herein by reference in their entirety.
TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic compounds.
1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido [2, 3-B]pyrazin- 8-yl)oxy]phenyl]urea derivatives as RAF inhibitors for the treatment of cancer
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RELATED APPLICATION
This application is related to: United Kingdom patent application number 1320729.5 filed 25 Nov. 2013, the contents of which are incorporated herein by reference in their entirety.
TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic
Agent for prevention and treatment of cancer comprising oxadiazole urea compound obstructing activity of stat
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CROSS-REFERENCE TO RELATED APPLICATION
This application claims the benefit of Korean Patent Application No. 10-2006-079561, filed Aug. 22, 2006 with the Korean Intellectual Property Office, the disclosure of which is incorporated herein in its entirety by reference.
BACKGROUND OF THE INVENTION
1.
Substituted pyrazolyl urea derivatives useful in the treatment of cancer
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FIELD OF THE INVENTION
This invention relates to novel compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g.,
Substituted pyrazolyl urea derivatives useful in the treatment of cancer
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FIELD OF THE INVENTION
This invention relates to novel compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g.,
Hydroxy methyl phenyl pyrazolyl urea compounds useful in the treatment of cancer
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FIELD OF THE INVENTION
This invention relates to novel hydroxy methyl phenyl pyrazolyl urea compounds, pharmaceutical compositions containing such compounds and the use of these compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in
Bicyclic urea derivatives useful in the treatment of cancer and other disorders
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FIELD OF THE INVENTION
This invention relates to novel compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g.,
N-acyl ureas exhibiting anti-cancer and anti-proliferative activities
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Dec. 14, 2009, is named 22035111.txt, and is 13,485 bytes in size.
FIELD OF THE INVENTION
The present
Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1
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TECHNICAL FIELD OF THE INVENTION
The present invention relates to compounds useful for inhibiting enzymes that maintain and repair the integrity of genetic material. More particularly, the present invention relates to a series of aryl- and heteroaryl-substituted urea compounds, methods of making the
N-acyl-N'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
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DESCRIPTION OF THE TEXT FILE SUBMITTED ELECTRONICALLY
The contents of the text file submitted electronically herewith are incorporated herein by reference in their entirety: A computer readable format copy of the Sequence Listing (filename: DECP_063_01US_SeqList_ST25.txt, date recorded: Mar. 15,
N-acyl-N'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
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FIELD OF THE INVENTION
Disclosed are compounds which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by
Ureas for the treatment and prevention of cancer
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BACKGROUND OF THE INVENTION
The Raf/MEK/ERK pathway is critical for cell survival, growth, proliferation and tumorigenesis. See, e.g., Nanxin Li, et al., Current Opinion in Investigational Drugs. Vol. 8, No. 6 (2007): 452-456. Raf kinases exist as three isoforms, A-Raf, B-Raf and C-Raf. Among the
Urea compound, preparation method therefor and medical use thereof
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PRIORITY CLAIM TO RELATED APPLICATIONS
This application is a U.S. national stage filing under 35 U.S.C. .sctn. 371 from International Application No. PCT/CN2017/076265, filed on 10 Mar. 2017, and published as WO2017/152874 on 14 Sep. 2017, which claims the benefit under 35 U.S.C. 119 to Chinese
Urea derivative or pharmacologically acceptable salt thereof
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is the National Stage of International Patent Application No. PCT/JP2016/002557 filed May 26, 2016, which claims priority from Japanese Patent Application No. 2015-107227 filed May 27, 2015, the disclosures of each of which are incorporated
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