An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed. The composition contains Bacopa monnieri extract comprising a Bacopa monnieri active ingredient; a Silybum marianum (milk thistle) extract comprising a Silybum marianum active ingredient; a Withania somnifera (ashwagandha) extract comprising a Withania somnifera active ingredient; a Camellia sinensis (green tea) extract comprising a Camellia sinensis active ingredient; a Curcuma longa (turmeric) extract comprising at least one Curcuma longa active ingredient, and optionally a Centella asiatica (Gotu kola) extract; a Ginko biloba extract; an Aloe vera extract; and N-acetyl cysteine. The process for quantifying Nrf2 transcription factor activating potential of the botanical extracts comprising the botanical active ingredients is described.

Lifeline Nutraceuticals Corporation

Compositions for alleviating inflammation and oxidative stress in a mammal

Method and compositions for reducing the inflammation after cytokine exposure of an islet cell transplant without affecting the viability and potency are disclosed herein. The present invention describes a composition comprising Withaferin A (WA), a steroidal lactone derived from Withania somnifera to effectively block NF-kB activation in beta cells, minimize cytokine-induced cell death and improve survival of transplanted islets. The method of the present invention involves identifying a subject having islet cells in need of treatment; and providing a effective amount of a Withaferin A composition disposed in a pharmaceutically acceptable carrier in an amount sufficient to reduce the inflammation after cytokine exposure without affecting the viability and potency of the islet cell population.

Naziruddin; Bashoo

Peng; Han

Matsumoto; Shinichi

Levy; Marlon F.

Baylor Research Institute

Method of achieving normoglycemia in diabetics by administration of Withaferin A

withania somnifera

inflamació

inflammation

withania

withania somnifera/inflamació

Compositions for alleviating inflammation and oxidative stress in a mammal

Method of achieving normoglycemia in diabetics by administration of Withaferin A

La base de dades d’herbes medicinals més completa avalada per la ciència