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8 resultats
Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats.
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Increased oxidative stress and antioxidant deficit have been suggested to play a major role in isoproterenol-induced myocardial infarction. The present study was designed to evaluate the effect of alpha-mangostin on the antioxidant defense system and lipid peroxidation against isoproterenol-induced
Protective effects of xanthones against myocardial ischemia-reperfusion injury in rats.
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OBJECTIVE
To investigate the protective effect of xanthones against myocardial ischemia-reperfusion injury in rats.
METHODS
Ischemia-reperfusion injury was induced by 20 min of global ischemia and 40 min of reperfusion in isolated rat hearts or 60-min coronary artery occlusion and 180-min
Protective effect of chlorogenic acid on the focal cerebral ischemia reperfusion rat models.
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OBJECTIVE
The aim of the study was to investigate the protective characteristic of chlorogenic acid, a natural glucosyl xanthone found in Lonicera Japonica on the cerebral ischemia reperfusion injury and the underlying mechanism.
METHODS
Focal cerebral ischemia reperfusion model was built by
3,4,5,6-Tetrahydroxyxanthone protects against myocardial ischemia-reperfusion injury in rats.
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In the present study, we tested the protective effect of 3,4,5,6-tetrahydroxyxanthone, a synthetic xanthone derivative, on myocardial ischemia-reperfusion injury in rats. Ischemia-reperfusion injury was induced by 30 min of global ischemia and 30 min of reperfusion in isolated rat hearts or 30 min
Protective effect of α-mangostin on cardiac reperfusion damage by attenuation of oxidative stress.
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This study was designed to investigate if α-mangostin (α-M), a xanthone present in the pericarp of Garcinia mangostana L., was able to protect against reperfusion injury in Langendorff-reperfused hearts. It was observed that α-M maintains the cardiac mechanical work, diminishes the area of infarct,
Protective effects of mangiferin on cerebral ischemia-reperfusion injury and its mechanisms.
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The aim of our study was to investigate the protective properties of mangiferin, a natural glucosyl xanthone found in both mango and papaya on the cerebral ischemia-reperfusion injury and the underlying mechanism. Wistar male rats were subjected to middle cerebral artery occlusion for 2h followed by
Screening of radical-scavenging natural neuroprotective antioxidants from Swertia chirayita.
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To detect and identify natural antioxidants in Swertia chirayita with protective effect against cerebral infarction, a screening method, using column chromatography and cerebral ischemia-reperfusion injury in rat, was developed. Seventeen compounds were purposefully separated and identified by
Cytoprotective effects of euxanthone against ox-LDL-induced endothelial cell injury is mediated via Nrf2.
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