The Use of Cranberries in Women With Preterm Premature Rupture of Membranes
Klíčová slova
Abstraktní
Popis
Preterm premature rupture of membranes (PPROM) complicates 2-3.5% of pregnancies and precipitates labor in 30-40% of preterm deliveries. The common practice in early PPROM with no evidence of chorioamnionitis is admission for close surveillance, antibiotic treatment and steroids for fetal lung maturation (until 32 weeks gestation. Intraamniotic infection is evident in up to 75% of women who develop labor during admission. The infection is for the most an ascending infection.
Cranberries have been recognized by the American Indians as a natural means for preventing urinary tract infection. The mechanism of action includes acidification of urine and inhibition of adhesion of pili-harboring bacteria to the transitional epithelium of the urinary tract.
We assume that cranberries will lower the rate of maternal urinary tract infection. Moreover, the active ingredients will pass transplacentally to the fetus, will be secreted in its urine hence, in the amniotic fluid. The active substances would coat the vagina and bring about their effect also in that environment. Having in mind that most if not all chorioamnionitis infections are caused by ascending infection, the cranberries might lengthen the latent period and reduce infectious maternal and neonatal morbidity.
Termíny
| Poslední ověření: | 02/28/2006 |
| První předloženo: | 10/30/2005 |
| Odhadovaná registrace vložena: | 10/30/2005 |
| První zveřejnění: | 10/31/2005 |
| Poslední aktualizace byla odeslána: | 04/09/2007 |
| Poslední aktualizace zveřejněna: | 04/10/2007 |
| Aktuální datum zahájení studie: | 04/30/2007 |
| Odhadované datum dokončení studie: | 01/31/2008 |
Stav nebo nemoc
Intervence / léčba
Drug: Cranberries - Vaccinium macrocarpon
Fáze
Kritéria způsobilosti
| Věky způsobilé ke studiu | 18 Years Na 18 Years |
| Pohlaví způsobilá ke studiu | Female |
| Přijímá zdravé dobrovolníky | Ano |
| Kritéria | Inclusion Criteria: - Proven premature rupture of membranes - less than 35 weeks of gestation with good obstetrical dating - no suspicion of amnionitis - signed informed consent Exclusion Criteria: - Known sensitivity / allergy to cranberries - Women treated with warfarin - Drug intolerance |
Výsledek
Primární výsledná opatření
1. Length (in days) of the latent period [undefined]
2. Neonatal infection [undefined]
3. Respiratory distress [undefined]
4. Admission to NICU (in days) [undefined]
5. Neonatal complications rate (NEC, IVH etc) [undefined]
6. Maternal infections (uterus, UTI) [undefined]
Měření sekundárních výsledků
1. Urinary and vaginal flora before and after treatment [undefined]
2. Vaginal pH before and after treatment [undefined]
3. Amniotic fluid pH before and after treatment [undefined]
