Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar
Klíčová slova
Abstraktní
Popis
The study was conducted in the Schistosoma haematobium high-endemic SIRAMA sugarcane plantation near the Ambilobe town in the northern province of Diego Suarez in Madagascar. A neighboring low-endemic village, Mataipako, was selected a control village. Participants aged 15 to 49 years old from SIRAMA were included in the study if positive for S.haematobium egg in urine.
A questionnaire addressing previous medical history and current urogenital symptoms was applied. A physical examination, including ultrasonophical (US) examination of urinary tract by transabdominal route, was undertaken. A pelvic examination, including transvaginal US was performed in women. In men, the prostate and the seminal vesicles were examined by transrectal US.
The following sexually transmitted infections (STI) were systematically assessed:
- Neisseria gonorrheae
- Chlamydia trachomatis
- Mycoplasma genitalium
- Trichomonas
- Treponema pallidum
- Herpes simplex 1 and 2
After baseline assessment, all participants (and partners) were systematically treated with an anti-STI regimen according to the existing guidelines by the Ministry of Health in Madagascar.
Re-assessment by questionnaire, physical examination and sampling for STIs was undertaken 4 weeks later followed by systematic praziquantel treatment to general community, including study participants.
A final follow-up study following the baseline protocol was conducted 5 months later.
Termíny
| Poslední ověření: | 06/30/2008 |
| První předloženo: | 07/07/2008 |
| Odhadovaná registrace vložena: | 07/10/2008 |
| První zveřejnění: | 07/13/2008 |
| Poslední aktualizace byla odeslána: | 07/10/2008 |
| Poslední aktualizace zveřejněna: | 07/13/2008 |
| Aktuální datum zahájení studie: | 07/31/2001 |
| Odhadované datum dokončení primární: | 03/31/2002 |
| Odhadované datum dokončení studie: | 08/31/2003 |
Stav nebo nemoc
Intervence / léčba
Drug: STI/PZQ 1
Fáze
Skupiny zbraní
| Paže | Intervence / léčba |
|---|---|
| Experimental: STI/PZQ 1 Baseline and post-treatment follow-up (anti-STI and praziquantel Rx) | Drug: STI/PZQ 1 Anti-STI regimen: ciprofloxacin 500mg orally, doxycycline 100mg BID orally 7 days and metronidazole 2g orally (cefuroxime im and/or azithromycin alternatively for pregnant and breastfeeding women) Anti-schistosoma regimen: Praziquantel 40mg/kg |
Kritéria způsobilosti
| Věky způsobilé ke studiu | 15 Years Na 15 Years |
| Pohlaví způsobilá ke studiu | All |
| Přijímá zdravé dobrovolníky | Ano |
| Kritéria | Inclusion Criteria: - adults - positive Schistosoma haematobium egg excretion in urine - signed written consensus Exclusion Criteria: - children - negative Schistosoma haematobium egg excretion in urine |
Výsledek
Primární výsledná opatření
1. Measurement of urogenital schistosomiasis and STI prevalence [2 months]
Měření sekundárních výsledků
1. Urogenital and STI associated morbidity [2 months]
