Bioorganic and Medicinal Chemistry Letters 1998-Sep
Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells.
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Abstraktní
Analogs of alpha-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common symthom, rac-Trolox (14) and are soluble/miscible at physiological pH. Compounds 4, 8, and 9 were found to have antiproliferative activity at micromolar concentrations.
