Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects.

Ten undescribed neo-clerodane diterpenoids, named hispanins A-J, together with six known ones, were isolated from the aerial parts of Salvia hispanica L. Their structures were established by extensive spectroscopic analysis. The absolute configurations of the undescribed compounds were determined by the ECD data and single crystal X-ray diffraction analysis. Hispanins B and C represented the first neo-clerodane diterpenoids with a unique oxygen bridge between C-19 and C-20. All isolated compounds were evaluated for their protective effects against H₂O₂-induced cardiomyocyte injury. Five of these compounds showed significant cardioprotective effects.