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Strana 1 z 29 Výsledek
Modulators for amyloid beta
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
PRIORITY TO RELATED APPLICATIONS(S)
This application claims the benefit of European Patent Application No. 08150173.6, filed Jan. 11, 2008, which is hereby incorporated by reference in its entirety.
BACKGROUND OF THE INVENTION
Alzheimer's disease (AD) is the most common cause of dementia in later
Method of diagnosis of amyloidoses
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The present invention relates generally to the field of proteins associated with neural lesions. More specifically, the present invention relates to the detection of protease nexin-2 (hereinafter "PN-2") and other precursors to amyloid deposited in the
Use of pyridinyl-pyrimidinylamino-benzamide derivatives for the treatment of amyloid related disorders
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The invention relates to the use of compounds (hereinafter: "COMPOUND") or a N-Oxide or a pharmaceutically acceptable salt thereof having an activity on protein kinases VEGFR-2, Tie-2, c-Src, c-Met, FGFR-1, Flt-1, HER-2, c-Abl, c-Raf, PDGFR-beta, c-Kit, or on a combination of the above enzymes, for
Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The invention relates to an improved method for preventing or treating vascular hemorrhaging. More specifically, the invention concerns methods for providing improved thrombolytic therapy to individuals who receive such therapy, and for diagnosing and treating diseases, such
Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The invention relates to an improved method for preventing or treating vascular hemorrhaging. More specifically, the invention concerns methods for providing improved thrombolytic therapy to individuals who receive such therapy, and for diagnosing and treating diseases, such
Modulators of amyloid beta
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION
Alzheimer's disease (AD) is the most common cause of dementia in later life. Pathologically, AD is characterized by the deposition of amyloid in extracellular plaques and intracellular neurofibrillary tangles in the brain. The amyloid plaques are mainly composed of
Modulators for amyloid beta
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION
Alzheimer's disease (AD) is the most common cause of dementia in later life. Pathologically, AD is characterized by the deposition of amyloid in extracellular plaques and intracellular neurofibrillary tangles in the brain. The amyloid plaques are mainly composed of
Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION
This invention relates to inhibitors of beta amyloid production, which have utility in the treatment of Alzheimer's disease.
Alzheimer's Disease (AD) is the most common form of dementia (loss of memory) in the elderly. The main pathological lesions of AD found in the
Bridged piperidine derivatives
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
PRIORITY TO RELATED APPLICATION(S)
This application claims the benefit of European Patent Application No 11156587.5, filed Mar. 2, 2011, which is hereby incorporated by reference in its entirety.
BACKGROUND OF THE INVENTION
Alzheimer's disease (AD) is the most common cause of dementia in later life.
Heteroaryl substituted piperidines
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
PRIORITY TO RELATED APPLICATION(S)
This application claims the benefit of European Patent Application No. 10153843.7, filed Feb. 17, 2010, which is hereby incorporated by reference in its entirety.
BACKGROUND OF THE INVENTION
Alzheimer's disease (AD) is the most common cause of dementia in later
Heterocyclic gamma secretase modulators
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
PRIORITY TO RELATED APPLICATION(S)
This application claims the benefit of European Patent Application No. 08168719.6, filed Nov. 10, 2008, which is hereby incorporated by reference in its entirety.
BACKGROUND OF THE INVENTION
Alzheimer's disease (AD) is the most common cause of dementia in later
Compounds and their use as BACE inhibitors
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
The prime neuropathological event distinguishing Alzheimer's disease (AD) is deposition of the 40-42 residue amyloid .beta. peptide (A.beta.) in brain parenchyma and cerebral vessels. A large body of genetic, biochemical and in vivo data supports a pivotal role for A.beta. in the
Mono-fluoro beta-secretase inhibitors
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The present invention relates to novel compounds and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as medicaments for treatment and/or prevention of various diseases. In particular the invention relates to
Compounds and their use as BACE inhibitors
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The present invention relates to compounds and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as medicaments for treatment and/or prevention of various diseases. In particular the invention relates to compounds, which are
Compounds and their use as BACE inhibitors
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The present invention relates to compounds and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as medicaments for treatment and/or prevention of various diseases. In particular the invention relates to compounds, which are
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