aniline/edém

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[Pulmonary edema in aniline paint poisoning].

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Přihlášení Registrace

Design, synthesis and preliminary pharmacological evaluation of new non-steroidal anti-inflammatory agents having a 4-(methylsulfonyl) aniline pharmacophore.

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Přihlášení Registrace

A series of 4-(methylsulfonyl)aniline derivatives were synthesized in order to obtain new compounds as a potential anti-inflammatory agents with expected selectivity against COX-2 enzyme. In vivo acute anti-inflammatory activity of the final compounds 11-14 was evaluated in rat using an egg-white

Lethal and sublethal effects of aniline and chlorinated anilines on zebrafish embryos and larvae.

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Přihlášení Registrace

Environmental risk assessments show increased attention to the sublethal effects of chemicals on aquatic organisms. The Organization for Economic Cooperation and Development (OECD) established the "Fish, Short-term Toxicity Test on Embryo and Sac-fry Stages" (OECD test 212) to predict lethal

Erythema Multiforme-like Secondary to Paraphenylenediamine Due to Henna Tattoo Plus Residual Hypopigmentation.

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Přihlášení Registrace

Temporary henna tattoos or pseudotattoos have become increasingly widespread among children and adolescent. A generalized skin reaction, type erythema multiforme-like reaction is unusual, and rarely reported. We describe the case of a 7-year-old boy who reported erythematous papular bull's-eye

Synthesis of N-phenylsulfonamide derivatives and investigation of some esterase enzymes inhibiting properties

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Přihlášení Registrace

In this study, synthesis of nine N-phenylsulfonamide derivatives was designed by starting from aniline, which is the simplest aromatic amine. These compounds were obtained in yields between 69 and 95%. Inhibitory properties of synthesized compounds on carbonic anhydrase I (CA I), CA II isoenzymes,

Studies on the mechanism of paracetamol-induced protection against paracetamol hepatotoxicity.

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Přihlášení Registrace

In rats, 3 days treatment with paracetamol (1 oral dose of 1 g/kg daily) produced a complete protection against the hepatotoxic actions of a further dose of paracetamol as documented by determination of serum enzyme activities (glutamic-oxaloacetic transaminase, (GOT), glutamic-pyruvic transaminase

Effects of long-term low-dose oxygen supplementation on the epithelial function, collagen metabolism and interstitial fibrogenesis in the guinea pig lung.

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Přihlášení Registrace

BACKGROUND The patient population receiving long-term oxygen therapy has increased with the rising morbidity of COPD. Although high-dose oxygen induces pulmonary edema and interstitial fibrosis, potential lung injury caused by long-term exposure to low-dose oxygen has not been fully analyzed. This

[Synthesis and antiinflammatory activity of 2-(E)-(4-hydroxy-3-methoxybenzylidene)-5-(N-substituted aminomethyl) cyclopentanones].

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Přihlášení Registrace

In search for new antiinflammatory agents, a series of 2-(E)-(4-hydroxy-3-methoxybenzylidene)-5-(N-substituted aminomethyl) cyclopentanones was synthesized via Stork reaction, Mannich reaction and amine exchange reaction. All of the fifteen target compounds were characterized by spectral analysis

Sex-related differences in drug-metabolizing enzyme activity of rats in carrageenan-induced inflammation.

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Přihlášení Registrace

Sex related differences in drugs metabolizing enzymes was studied using Wistar-rats bearing carrageenan-induced edema. One day after treatment with carrageenan, aminopyrine N-demethylase activity was inhibited in males but not in females. Carrageenan treatment did not alter the activity of aniline

Assessment of the lethal and sublethal effects of 20 environmental chemicals in zebrafish embryos and larvae by using OECD TG 212.

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Přihlášení Registrace

Fish embryo toxicity tests are used to assess the lethal and sublethal effects of environmental chemicals in aquatic organisms. Previously, we used a short-term toxicity test published by the Organization for Economic Co-operation and Development (test no. 212: Fish, Short-term Toxicity Test on

Developmental disorders in embryos of the frog Xenopus laevis induced by chloroacetanilide herbicides and their degradation products.

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Přihlášení Registrace

Pesticides are known to transform in the environment, but so far the study of their effects in the environment has concentrated on the parent compounds, thereby neglecting the effects of the degradation products. The embryotoxic, developmental, and teratogenic effects of chloroacetanilide herbicides

2-Bromo-1-hydroxyquinolizinium bromide substituted anilinium salts: a new class of anti-inflammatory agents.

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Přihlášení Registrace

A series of 2-bromo-1-hydroxyquinolizinium bromide substituted anilinium salts have been prepared by reaction of 1-acetoxy-2-bromoquinolizinium bromide with an appropriately substituted aniline. The resulting anilinium derivatives exhibited a moderate to high degree of anti-inflammatory activity in

(E)-2-Cyano-3-(1H-Indol-3-yl)-N-Phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of the Anti-Inflammatory Potential.

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Přihlášení Registrace

The compound (E)-2-cyano-3-(1H-indol-3-yl)-N-phenylacrylamide (ICMD-01) was designed and developed based on the structures of clinically relevant drugs indomethacin and paracetamol through the molecular hybridization strategy. This derivative was obtained by an amidation reaction between substituted

Synthesis and anti-inflammatory and analgesic activities of 3-methyl-N-phenyl-1H-pyrazol-5-ylcarboxamides.

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Přihlášení Registrace

The anti-inflammatory and analgesic activities of a series of 3-methyl-N-phenyl-1H-pyrazol-5-ylcarboxamides were investigated and compared with flufenamic acid. The compounds were synthesized by condensation of diketopiperazines 2 with the appropriate aniline. The pharmacological tests showed that

Synthesis of Some New Hydroxytriazenes and their Antimicrobial and Anti-inflammatory activities.

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Přihlášení Registrace

Hydroxytriazenes and their derivatives have been studied for the biological and pharmacological applications in the past few years. These compounds possess antibacterial, antifungal, anti-inflammatory, analgesic and wound healing activities. In this study, we report the synthesis of

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