Ovarian Cancer

Endometrial Cancer

This trial is limited to female participants, as it is a study of ovarian and endometrial cancer patients.

Participants in the usual care plus ketogenic diet group will receive usual care plus dietary counseling in accordance with a ketogenic diet such that ~5% energy comes from carbohydrate, 25% energy from protein, and 70% energy from fat for the duration of the 12 week study.

Ketogenic diet

Participants in the usual care plus AND diet group will receive usual care plus dietary counseling in accordance with the Academy of Nutrition and Dietetics guidelines in 2013 for the duration of the 12 week study.

AND diet

Targeted Disruption to Cancer Metabolism and Growth Through Dietary Macronutrient Modification

Targeted Disruption to Cancer Metabolism Through Dietary Macronutrient Modification

fasting serum concentrations of a variety of inflammatory markers

Physical and mental health functioning as assessed by the Medical outcomes Study Short Form-12 Health Survey, which produces a physical component summary and mental component summary score.

Perceived hunger assessed by a visual analog scale

Cravings for particular types foods (fats, sweets, starches) as assessed by the Food Craving Inventory

fasting serum concentrations of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides

Barbara Gower

Professor

University of Alabama at Birmingham

American Institute for Cancer Research

This study is a randomized clinical trial with a parallel arm design to evaluate the effects of 12 weeks of usual care plus AND or usual care plus KD on women with ovarian and endometrial cancer.

Standard diet (SD): Nutrition following the standard recommendations of the German society for nutrition

Nutritional intervention: Ketogenic diet (KD).
Intervention: Nutritional support (hospital) + self support (outpatient phase) with KD

Nutritional intervention: low glycämic and insulinemic" diet (LOGI)
Intervention: Nutritional support (hospital) + self support (outpatient phase) with LOGI

Quality of Life

Nutrition intervention following the recommendations of the germans society for nutrition (DGE)

Standard diet (SD)

Nutritional intervention: recommendations to follow a ketogenic diet

Experimental 1: Ketogenic diet (KD).

Nutritional intervention: patients were instructed to follow the "LOGI" diet regimen

Experimental 2: "Low glycämic and insulinemic" diet (LOGI)

Hompage of the clinic in which the study is about to be accomplished.

Rehaklinik Am Kurpark

Ketogenic Or LOGI Diet In a Breast Cancer Rehabilitation Intervention (KOLIBRI)

To study the effect of a ketogenic diet (KD) or a low glycämic and insulinemic diet (LOGI) compared to a standard diet (SD) on quality of life in patients with Breast Cancer during the rehabilitation phase.
This will be done by comparing the results of the EORTC QLQ-30 and the QLQ-BR23 questionnaires.

For all patients in the three groups (KD, LOGI and SD ) in parallel:
Feasibility measured as average calorie and carbohydrate intake per day during weeks 1-20 as documented by food diary at one random day/week Safety as defined as number of patients with adverse events [ Time Frame: weeks 1-20] Ketosis as dokumented daily in urine and blood [Time Frame: days 1-21] and in urine daily [Time Frame: week 4-20) Physical performance as obtained by spiroergometry [Time frame: day 1, day 21 and week 20] Body composition as analyzed by standard-Bioimpedance analysis(BIA), Dual- measurement [Time frame: day 1, 21 and week 20] Metabolic parameters (triglycerides, cholesterine, glucose, insulin, IGF-1) in patients serum via standard laboratory procedure [Time frame: day 1, 21, week 11 and 20]

For all patients in the three groups (KD, LOGI and SD ) in parallel:
Feasibility measured as average calorie and carbohydrate intake per day during weeks 1-20 as documented by food diary at one random day/week tolerability as defined as number of patients with adverse events [ Time Frame: weeks 1-20] Ketosis as dokumented daily in urine and blood [Time Frame: days 1-21] and in urine daily [Time Frame: week 4-20) Physical performance as obtained by spiroergometry [Time frame: day 1, day 21 and week 20] Body composition as analyzed by standard-Bioimpedance analysis(BIA), Dual- measurement [Time frame: day 1, 21 and week 20] Metabolic parameters (triglycerides, cholesterine, glucose, insulin, IGF-1) in patients serum via standard laboratory procedure [Time frame: day 1, 21, week 11 and 20]

Marc Sütterlin, MD, PhD

Universitätsmedizin Mannheim

Test burgers with fresh avocado added just prior to consumption

Participants consumed 250 g cooked ground beef patty with or without 68 g fresh avocado added prior to ingestion.

Consumption of Beef Patty With or Without Avocado

Sex/Gender, Customized

Race/Ethnicity, Customized

Region of Enrollment

Change from baseline in reactive hyperemia index (RHI) in response to consumption of 250 g beef patty with or without 68 g avocado added at 2 hour post-ingestion. RHI is a measure of endothelial dysfunction using noninvasive peripheral arterial tonometry (PAT). It is a ratio of the post-to-pre occlusion PAT amplitude of the tested arm, divided by the post-to-pre occlusion ratio of the control arm. RHI less than 1.67 is considered sign of endothelial dysfunction and RHI equal to or greater than 1.67 is considered normal function. The possible range of scores is 1 to 3. Increasing score indicates the improvement of coronary endothelial function.

Participants consumed 250 g beef patties without avocado added

Participants Consumed 250 g Beef Patties Alone

Participants consumed 250 g beef patties with 68 g avocado added prior to ingestion.

Participants Consumed 250 g Beef Patties With Avocado Added

Change of Endothelial Function by Measurement of Flow-mediated Vasodilation Using the Reactive Hyperemia Index (RHI)

Change from baseline inflammatory marker IkB-alpha in response to the consumption of 250 g beef patty with or without 68 g avocado added was assessed at 0 (baseline), 1, 2, 3, 4, 5, 6 hours post-ingestion. Baseline and 3 hours post-ingestion was reported.

Participants consumed 250 g beef patties without avocado added prior to ingestion.

Consumption of Beef Patty Alone

Consumption of 250 g Beef Patty With Avocado Added

Change in Inflammation Marker Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-cells Inhibitor Alpha (IkB-alpha)

Participants consumed 250 g cooked ground beef patty with or without avocado added prior to ingestion.

Consumption of Beef Patty With or Without Avocado Added

Consumption of Beef Patty With Avocado

Zhaoping Li

Change in peripheral arterial tonometry (PAT) after consuming meals consisting of a ground beef patty only.

Change in PAT After Consuming Beef Only

Change in peripheral arterial tonometry (PAT) after consuming meals consisting of a ground beef patty with 68 grams of avocado added.

avocado/rakovina

Targeted Disruption to Cancer Metabolism and Growth Through Dietary Macronutrient Modification

Ketogenic Or LOGI Diet In a Breast Cancer Rehabilitation Intervention (KOLIBRI)

Effects of Avocado When Added to a Meat Patty on Inflammation in Healthy Men

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