PROBLEM TO BE SOLVED A burdock fruit extract containing arctigenin at high content and its production method are provided, and both of which are used for treatment of pancreatic cancer. SOLUTION The burdock fruit extract containing arctigenin at high content by enzymatically converted arctiin into arctigenin with beta-glucosidase, which is an enzyme occurring endogenously in a burdock fruit, and adding ethanol, extracting, concentrating and then freeze-drying or spray drying.

Yamamoto; Keiichi

Okubo; Toshiki

Yomoda; Satoshi

Esumi; Hiroyasu

Miyoshi; Chika

Kadota; Shigetoshi

Kracie Pharma, Ltd.

Japan as Represented by President of National Cancer Center

National University Corporation University of Toyama

Burdock fruit extract containing arctigenin at high content and process for producing same

A novel substance that has the physiological activity of the aglycone of isoflavones and the physiological activity of the culture of the basidiomycetes with the physiological activities being synergistically enhanced, obtained by cultivating a basidiomycetes having a .beta.-glucosidase activity in a medium containing an isoflavone, a method for producing it, and food, feedstuff and medicine containing it. The substance of the invention is improved in the physiological effect of the aglycone of isoflavones and the physiological effect of the culture of the basidiomycetes, and is not only useful as an anti-tumor agent but also is useful for therapy and/or prevention of osteoporosis and also as an immune enhancement agent.

Amino Up Chemical Co., Ltd.

Substance derived from basidiomycetes culture, method for producing it and its use

beta glucosidase

rakovina

neoplasms

beta glucosidase/rakovina

Burdock fruit extract containing arctigenin at high content and process for producing same

Substance derived from basidiomycetes culture, method for producing it and its use

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