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bicuculline/zánět
Odkaz je uložen do schránky
Strana 1 z 120 Výsledek
Intrathecal bicuculline does not increase formalin-induced inflammation.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Intrathecal (i.t.) administration of the gamma-aminobutyric acid (GABA)A receptor antagonist bicuculline enhances pain behaviors in the formalin test. This study examined whether bicuculline also increases the peripheral inflammation induced by formalin. Subcutaneous injection of 0.25 to 5.0%
Joint inflammation and hyperalgesia are reduced by spinal bicuculline.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Knee joint injection of kaolin and carrageenan produces acute inflammation with localized joint swelling and increased temperature. This inflammation results in behavioral changes, including limping and guarding of the limb, and heat hyperalgesia. Prior spinal cord infusion of bicuculline, a gamma
GABAergic mechanisms are involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory hyperalgesia.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
OBJECTIVE
The purpose of this study was to investigate the involvement of GABAergic mechanisms in the antihyperalgesic effect of carbamazepine and oxcarbazepine by examining the effect of bicuculline (GABA(A) receptor antagonist) on these effects of antiepileptic drugs.
METHODS
Rats were
(+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Chronic pain is a major public health problem categorized as inflammatory or neuropathic, each involving impaired GABAergic control in the spinal cord of mammals. (+)-Borneol, a bicyclic monoterpene present in the essential oil of plants, is used for analgesia and anesthesia in traditional Chinese
Vocalization responses after spinal administration of bicuculline or strychnine in rats.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Objective. Spinal administration of compounds decreasing inhibition of spinal nociceptive pathways, such as antagonists of GABA or glycine receptors, leads to vocalization. This can be quantified semiautomatically and could be used as a research model. Materials and Methods. Vocalization after
Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Despite common pathophysiological mechanisms, inflammatory and neuropathic pain do not respond equally to the analgesic effect of antidepressants, except for selective serotonin reuptake inhibitors (SSRIs), which show a limited efficacy in both conditions. We previously demonstrated that an
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Plastic changes in the amygdala and limbic cortex networks have been widely shown in chronic pain. We have here investigated the role of group I metabotropic glutamate receptors (mGluRs) in the basolateral amygdala (BLA) pre-infra-limbic (PL-IL) divisions of the medial prefrontal cortex (mPFC)
Evidence that GABAergic neurons in the spinal trigeminal nucleus are involved in the transmission of inflammatory pain in the rat: a microdialysis and pharmacological study.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The aim of this experiment was to investigate the role of the gamma-aminobutyric acid (GABA)-ergic transmission in the nociception within the spinal trigeminal nucleus. The formalin test was used as an animal model of inflammatory pain. Two groups of six rats were used. The behavioural response to
Indomethacin/ibuprofen-like anti-inflammatory agents selectively potentiate the gamma-aminobutyric acid-antagonistic effects of several norfloxacin-like quinolone antibacterial agents on [35S]t-butylbicyclophosphorothionate binding.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Four piperazinoquinolone antibacterial drugs (norfloxacin, ciprofloxacin, enoxacin, and pipemidic acid), known to be gamma-aminobutyric acid (GABA) antagonists, fully reversed the inhibitory effect of GABA on [35S]t-butylbicyclophosphorothionate ([35S] TBPS) binding to rat brain membranes in vitro.
Bicuculline enhances the corticosterone secretion induced by lipopolysaccharide and interleukin-1 alpha in male rats.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Lipopolysaccharide (LPS)-induced inflammatory stress activates the hypothalamus-pituitary-adrenal (HPA) function. Interleukin-I (IL-1) is one of the key factors during this event; however, the mechanisms mediating IL-1 stimulation of HPA axis are still unclear. The present study evaluated the
The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
OBJECTIVE
Levetiracetam, a novel antiepileptic drug, has recently been shown to have antinociceptive effects in various animal models of pain. The purpose of this study was to investigate the antihyperalgesic effect of levetiracetam and its mechanism of action, by examining the involvement of
Dorsal root reflexes and cutaneous neurogenic inflammation after intradermal injection of capsaicin in rats.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The role of dorsal root reflexes (DRRs) in acute cutaneous neurogenic inflammation induced by intradermal injection of capsaicin (CAP) was examined in anesthetized rats. Changes in cutaneous blood flow (flare) on the plantar surface of the foot were measured using a laser Doppler flowmeter, and
The antinociceptive effect of artemisinin on the inflammatory pain and role of GABAergic and opioidergic systems.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Bicuculline Reverts the Neuroprotective Effects of Meloxicam in an Oxygen and Glucose Deprivation (OGD) Model of Organotypic Hippocampal Slice Cultures.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
We previously demonstrated that the non-steroidal anti-inflammatory agent meloxicam has neuroprotective effects in an oxygen and glucose deprivation model (OGD) of rat organotypic hippocampal slice cultures. We wondered if GABAergic transmission changed the neuroprotective effects of meloxicam and
The mechanisms of antihyperalgesic effect of topiramate in a rat model of inflammatory hyperalgesia.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Recent studies have shown that topiramate, a structurally novel anticonvulsant, exerts antinociceptive activity in animal models of neuropathic, acute somatic, and visceral pain. This study was aimed to examine: (i) the effects of systemically and locally peripherally administered topiramate in the
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