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carbonic anhydrase/sarkom
Odkaz je uložen do schránky
Strana 1 z 20 Výsledek
Carbonic anhydrase IX as a marker for poor prognosis in soft tissue sarcoma.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
OBJECTIVE
Hypoxia is associated with malignant progression and poor outcome in several human tumors, including soft tissue sarcoma. Recent studies have suggested that carbonic anhydrase (CA) IX is an intrinsic marker of hypoxia, and that CA IX correlates with poor prognosis in several types of
Can sparsely and heterogeneously expressed proteins be detected using tissue microarrays? A simulation study of the hypoxia marker carbonic anhydrase IX (CA IX) in human soft tissue sarcoma.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Tissue microarrays (TMAs) are often used to evaluate the expression of biological markers across large patient populations. We investigated the number of core biopsies required to accurately classify soft tissue sarcomas with respect to their expression of carbonic anhydrase IX (CA IX), a potential
[Activity of ceruloplasmin, carbonic anhydrase and saturation of transferrin with iron in blood serum of rats developing experimental sarcoma M-1 against a background of E-avitaminosis].
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial,
Endosialin and Associated Protein Expression in Soft Tissue Sarcomas: A Potential Target for Anti-Endosialin Therapeutic Strategies.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Endosialin (CD248, TEM-1) is expressed in pericytes, tumor vasculature, tumor fibroblasts, and some tumor cells, including sarcomas, with limited normal tissue expression, and appears to play a key role in tumor-stromal interactions, including angiogenesis. Monoclonal antibodies targeting endosialin
Carbonic anhydrase isozymes II, IX, and XII in uterine tumors.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Histopathological diagnostics of gynecological malignancies continues to be challenging despite the well established criteria. For example, the morphological distinction of uterine leiomyosarcoma from certain variants of benign leiomyoma can be difficult. Herein, we investigated the expression of
Prognostic impacts of hypoxic markers in soft tissue sarcoma.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with
Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
OBJECTIVE
To examine the addition of genetic or pharmacologic inhibition of hypoxia-inducible factor 1α (HIF-1α) to radiation therapy (RT) and vascular endothelial growth factor A (VEGF-A) inhibition (ie trimodality therapy) for soft-tissue sarcoma.
METHODS
Hypoxia-inducible factor 1α was inhibited
Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Acridine orange (AO) a fluorescent cationic dye used for the management of human musculoskeletal sarcomas, due to its strong tumoricidal action and accumulation in the acidic environment typical of hypoxic tumors, was used for the preparation of a primary sulfonamide derivative. The rationale behind
Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Gastrointestinal stromal tumors (GISTs) are clinically distinct mesenchymal tumors, which generally result from expression of mutant KIT or PDGFRA receptor tyrosine kinase oncogenes. Most GISTs feature strong expression of KIT that serves as a crucial diagnostic adjunct. However, a subset of tumors
The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Despite high metastasis rates, adjuvant/neoadjuvant systemic therapy for localised soft tissue sarcoma (STS) is not used routinely. Progress requires tailoring therapy to features of tumour biology, which need exploration in well-documented cohorts. Hypoxia has been linked to metastasis
Expression of hypoxic markers and their prognostic significance in soft tissue sarcoma.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Tumor hypoxia is significant in promoting tumor progression and resistance to therapy, and hypoxia-inducible factor 1α (HIF-1α) is essential in the adaptive response of cells to hypoxia. The aim of the present study was to investigate the expression of hypoxic markers and evaluate their prognostic
A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Protein tyrosine phosphatases, on purely theoretical grounds, were suggested as possible tumor suppressor genes, and receptor protein tyrosine phosphatase gamma (PTPRG) has been proposed, on the basis of its location at human chromosome region 3p14.2, specifically as a tumor suppressor gene for
Endogenous markers of tumor hypoxia predictors of clinical radiation resistance?
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Eppendorf electrode measurements of tumor oxygenation have defined an adverse effect of tumor hypoxia on prognosis after radiotherapy and other treatment modalities, in particular in head and neck and cervix carcinomas as well as soft tissue sarcomas. Recently, the immunohistochemical
Extraskeletal myxoid chondrosarcoma of the vulva with PLAG1 gene activation: molecular genetic characterization of 2 cases.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal neoplasm, rarely reported in the genitourinary tract with only 5 cases reported in the vulva. We investigated 2 cases of vulvar sarcomas whose morphologic appearance and immunohistochemical profiles were consistent with EMC using
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