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cardenolide/zánět
Odkaz je uložen do schránky
14 Výsledek
Chemical Access to d-Sarmentose Units Enables the Total Synthesis of Cardenolide Monoglycoside N-1 from Nerium oleander.
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Přihlášení Registrace
Herein we present a chemical approach for the ready preparation of d-sarmentosyl donors enabling the first total synthesis and structure validation of cardenolide N-1, a challenging 2,6-dideoxy-3-O-methyl-β-d-xylo-hexopyranoside extracted from Nerium oleander twigs that displays anti-inflammatory
The structure of a new cardenolide diglycoside and the biological activities of eleven cardenolide diglycosides from Nerium oleander.
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Přihlášení Registrace
A new cardenolide diglycoside (1) was isolated from Nerium oleander together with ten known cardenolide diglycosides 2-11. The structure of compound 1 was established on the basis of their spectroscopic data. The in vitro anti-inflammatory activity of compounds 1-11 was examined on the basis of
Analgesic and anti-inflammatory properties of the leaf extracts of Anacardium occidentalis in the laboratory rodents.
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Přihlášení Registrace
Anacardium occidentalis (family: Anacardiaceae) is a plant of the tropical climate widely used by folklore to treat pain and inflammation. This study was conducted to evaluate the analgesic and anti-inflammatory effects of the leaf extracts in rat and mice using different models in other to confirm
Anti-inflammatory, Anti-nociceptive and Total polyphenolic Content of Hydroethanolic Extract of Ocimum gratissimum L. Leaves.
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Přihlášení Registrace
Ocimum gratissimum has been reported in several ethnopharmacological surveys as a plant readily accessible to the communities and widely used with a lot of therapeutic potentials. In this study, we aimed to experimentally evaluate the anti-inflammatory effects of hydro-ethanolic extract in animal
Bioactive cardenolides from the stems and twigs of Nerium oleander.
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Přihlášení Registrace
Four new cardenolide monoglycosides, cardenolides N-1 (1), N-2 (2), N-3 (3), and N-4 (4), were isolated from Nerium oleander, together with two known cardenolides, 5 and 12, and seven cardenolide monoglycosides, 6-11 and 13. The structures of compounds 1-4 were established on the basis of their
The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice.
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Přihlášení Registrace
The current study aimed to investigate the protective effect of the cardenolide glycoside acovenoside A (AcoA) against doxorubicin-induced cardiotoxicity in mice. AcoA was isolated from the pericarps of Acokanthera oppositifolia to chemical homogeneity and characterized by means of one- and
Cytotoxic and anti-inflammatory constituents from the seeds of Descurainia sophia.
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Přihlášení Registrace
A new sinapoyl glycoside, 1,3-di-O-sinapoyl-β-D-glucopyranose (1) along with 13 known compounds, including, sinapoyl glycosides (2 and 3), cardenolide glycoside (4), flavonoids (5-10), lignan (11), phenolic acids (12 and 13), and phytosterol (14), were isolated from the seeds of Descurainia sophia
Anti-histaminic potential of fractions from Hedranthera barteri [(Hook F.) Pichon] root in laboratory rodents.
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Přihlášení Registrace
Hedranthera barteri, anti-inflammatory activity, anti-nociceptive activity, anti-histaminic activityL. (HB) is used in the treatment of painful conditions and oedema amongst its folkloric use. The hexane and ethyl acetate fractions of the root of H. barteri were investigated for anti-nociceptive and
Summer pheasant's eye (Adonis aestivalis) poisoning in three horses.
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Přihlášení Registrace
Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding initially presented
Drug Repurposing for Retinoblastoma: Recent Advances.
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Přihlášení Registrace
Retinoblastoma is the intraocular malignancy that occurs during early childhood. The current standard of care includes chemotherapy followed by focal consolidative therapies, and enucleation. Unfortunately, these are associated with many side and late effects. New drugs and/or drug combinations need
Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer.
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Přihlášení Registrace
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis. Initially, TGFβ is a tumor suppressor, but in advanced metastatic disease it
Apocynaceae species with antiproliferative and/or antiplasmodial properties: a review of ten genera.
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Přihlášení Registrace
Apocynaceae is a large family of tropical trees, shrubs and vines with most species producing white latex. Major metabolites of species are triterpenoids, iridoids, alkaloids and cardenolides, which are known for a wide range of biological and pharmacological activities such as cardioprotective,
Mallotus philippinensis Muell. Arg (Euphorbiaceae): ethnopharmacology and phytochemistry review.
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Přihlášení Registrace
Mallotus philippinensis Muell. Arg (Euphorbiaceae) are widely distributed perennial shrub or small tree in tropical and subtropical region in outer Himalayas regions with an altitude below 1,000 m and are reported to have wide range of pharmacological activities. Mallotus philippinensis species are
UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death.
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Přihlášení Registrace
Despite significant progress in oncology therapeutics in the last decades, the urge to discover and to develop new, alternative or synergistic anti-cancer agents still remains. For centuries it has been known that the coarse shrub Calotropis procera is a very promising source of ascaricidal,
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