The present invention relates to microorganisms for preventing or treating obesity or diabetes mellitus which have excellent viability and produce polysaccharides efficiently in the intestines. More particularly, is directed to microorganisms for preventing or treating obesity or diabetes mellitus, which are capable of reducing the amount of monosaccharides or disaccharides that can be absorbed into the intestine by converting those mono or disaccharides into polymeric materials that cannot be absorbed in the intestines. The present invention is also directed to a pharmaceutical composition containing pharmaceutically effective amount of the microorganisms and a food composition containing the microorganisms as an active ingredient. Preferred microorganisms are Lactobacillus reuteri KCTC-10301BP and Lactobacillus fermentum KCTC-10458BP.

Bioneer Corporation

Microorganisms for preventing and/or treating obesity or diabetes mellitus

To reduce the glycemic load in the daily nutrition of diabetics, obese and for weight-reducing diets, this invention claims cooking or baking processes and other procedures for food--rich in carbohydrates--in which the structure of the raw complex carbohydrates is mostly preserved and/or short saccharides are encapsulated. This objective is attained by reducing the magnitude of the complex carbohydrate fractioning by the undesired effect of adiabatic heating during grain grinding, or during conventional cooking and also through the encapsulation of already processed monosaccharide's, disaccharides or broken carbohydrate chains in capsules within denaturalized protein matrixes, in order to make their digestion deeper and longer. These processes and procedures allow the ingestion of less restricted portions of food, very similar to the conventional ones while due to their prolonged digestion, naturally limiting the immediate production of glucose (Glycemic Index).

Zapp Glauser; Jorge Luis

Processing and cooking of food with a low glycemic impact for the nutrition of diabetics, obese and for weight reducing diets

Control of weight gain has long been a problem for many people who if they lose weight by dieting often gain it back in a short period of time. Therefore, there has been much research to find a simple means to control weight in humans.Acarbose, an oligosaccharide, is an oral alpha glucosidase inhibitor. The mechanism of action of acarbose results from a competitive inhibition of pancreatic amylase and membrane bound intestinal aplpha-glucoside hydrolase enzymes. Pancreatic alpha amylase hydrolizes complex starches in the lumen of the small intestine. The membrane bound intestinal alpha glucosidases hydrolyze oligo saccharides, trissaccharides and disaccharides to glucose and other monosaccharides in the brush boarder of the small intestines. It has no inhibitory effect against lactase and would therefore not be expected to induce the symptoms of lactose intolerance. The weight gain or loss for an individual is essentially the difference between the calories absorbed and the calories burned.

Use for drug acarbose precose for weight control prevention of weight gain for weight loss for treatment and prevention of obesity

The invention relates to a combination of heat-treated nutritional composition having a carbohydrate fraction comprising a) 5-30 wt % of one or more monosaccharides selected from galactose, ribose and mannose; b) carbohydrates capable of providing b1) sustained release glucose and b2) rapidly available glucose; c) optionally fructose; d) glucose-containing disaccharides other than maltose and sucrose; and e) optionally sugar polyols. The invention also pertains to the use of such a heat-treated nutritional composition for controlling glucose levels in blood and/or tissue, especially for preventing and/or treating diabetics, insulin-resistance, obesity, postprandial glucose response, metabolic syndrome, syndrome X, hyperglycemia, hypertriglyceridemia, hyperinsulinemia, dyslipidemia, dysfibrinolysis and/or disorders associated with major surgery or trauma.

disaccharide/obezita

Microorganisms for preventing and/or treating obesity or diabetes mellitus

Processing and cooking of food with a low glycemic impact for the nutrition of diabetics, obese and for weight reducing diets

Use for drug acarbose precose for weight control prevention of weight gain for weight loss for treatment and prevention of obesity

Carbohydrate fraction and use thereof for a flat postprandial glucose response

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