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disulfide/rakovina

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Strana 1 z 132 Výsledek

Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer

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Přihlášení Registrace
The present invention relates to the cancerology field. More particularly, the subject of the present invention is a method for the in vitro diagnosis of colorectal cancer in a human patient, by determining the presence of protein disulfide isomerase (PDI) in a biological sample taken from this

Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The present invention relates to the cancerology field. More particularly, the subject of the present invention is a method for the in vitro diagnosis of colorectal cancer in a human patient, by determining the presence of protein disulfide isomerase (PDI) in a biological sample taken from this

Method of treating cancer using tetraethyl thiuram disulfide

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Přihlášení Registrace
FIELD OF INVENTION This invention generally relates to methods of treating cancer, and particularly to methods of treating cancer using dithiocarbamate. BACKGROUND OF THE INVENTION Cancer, the uncontrolled growth of malignant cells, is a major health problem of the modern medical era and ranks

Colon tumor specific binding peptides

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Přihlášení Registrace
BACKGROUND OF THE INVENTION Colon carcinogenesis is thought to be a stepwise process that involves the transition of normal colon epithelium to neoplasm. The multistep progression of the disease requires years and possibly decades, and therefore apparently provides ample time for diagnosis and

Anti-bFGF humanized double-stranded antibody with stable disulfide bond, preparation method and application thereof

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Přihlášení Registrace
CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a national phase entry under 35 U.S.C. .sctn.371 of International Application No. PCT/CN2012/080357 filed on Aug. 20, 2012, published in Chinese, which claims the benefit of China Patent Application No. 201110450855.0 filed Dec. 28,

Disulfide-linked multivalent MHC class I comprising multi-function proteins

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Přihlášení Registrace
CROSS-REFERENCE TO RELATED APPLICATIONS This application is a 371 of PCT International Application No. PCT/EP2013/077109, filed on Dec. 18, 2013, currently pending, the contents of which are incorporated by reference in its entirety, and which claims priority to European Application No.

Tethering cysteine residues using cyclic disulfides

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Přihlášení Registrace
BACKGROUND OF THE INVENTION Many therapeutic molecules form covalent bonds with cysteine residues on their protein targets. The mechanisms of the majority of these molecules were either elucidated long after development or are not fully understood. Recent successful drug discovery efforts, however,

Amino disulfides

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Přihlášení Registrace
FIELD OF THE INVENTION The present invention refers to mitomycin analogs containing a disulfide group (Class 260 Subclass 326.24). These compounds are mitomycin C derivatives in which the 7-amino group bears an organic substituent incorporating a disulfide group. These compounds are inhibitors of

Diphenyl disulfide compounds

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Přihlášení Registrace
FIELD OF THE INVENTION This invention relates to novel diphenyl disulfide compounds having the activities to inhibit the production of Interleukin-1.beta. (IL-1.beta.) and the release of Tumor Necrosis Factor.alpha. (TNF.alpha.). BACKGROUND OF THE INVENTION IL-1.beta. is a protein produced mainly

Amino disulfide thiol exchange products

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Přihlášení Registrace
FIELD OF THE INVENTION The present compounds are mitomycin C analogs (Class 548, Subclass 422) in which the 7-amino group is substituted by a disulfide containing organic group. These compounds are inhibitors of experimental animal tumors. BACKGROUND OF THE INVENTION Nomenclature--The systematic

Protein particles comprising disulfide crosslinkers and uses

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED AS A TEXT FILE VIA THE OFFICE ELECTRONIC FILING SYSTEM (EFS-WEB) The Sequence Listing associated with this application is provided in text format in lieu of a paper copy, and is hereby incorporated by reference into the specification. The name of the

Protein particles comprising disulfide crosslinkers and uses related thereto

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED AS A TEXT FILE VIA THE OFFICE ELECTRONIC FILING SYSTEM (EFS-WEB) The Sequence Listing associated with this application is provided in text format in lieu of a paper copy, and is hereby incorporated by reference into the specification. The name of the

Carbonate polymer containing a functional group of disulfide five-membered ring in the side chain and application thereof

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Přihlášení Registrace
TECHNICAL FIELD The invention relates to a biodegradable polymer material and its application, in particular to a carbonate polymer containing a functional group of disulfide five-membered ring in the side chain and its application, belonging to the field of medical material. BACKGROUND

Liver cancer biomarkers

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Přihlášení Registrace
FIELD OF THE INVENTION The present invention concerns methods of screening for or detecting liver cancer in subjects, including subjects with or without previously detected risk factors for liver cancer. BACKGROUND OF THE INVENTION Hepatocellular carcinoma (HCC), the major histological form of

Polymer/copper combination for targeted cancer therapy

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Přihlášení Registrace
BACKGROUND Although various anticancer drugs have been developed in an attempt to conquer cancer, a large number of cancer patients ultimately still lose their battle. There are two major causes for this failure: inherited or acquired drug resistance by the cancer cells and side effects due to the
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