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FIELD OF THE INVENTION
This invention relates generally to pyrrolidinyl cyclic disulfide compounds which are useful therapeutic agents for the treatment of inflammatory diseases.
BACKGROUND OF THE INVENTION
Vascular cell adhesion molecule-1 (VCAM-1), a member of the immunoglobulin (Ig) supergene
DETAILED DESCRIPTION OF THE INVENTION
The present invention is directed to bis(2-benzylaminoethyl)disulfides of the formula ##STR1## (hereinafter referred to as "disulfides"), wherein R and R"" independently are hydrogen, hydroxy, halogen or loweralkyloxy, R' and R'" independently are hydrogen,
BACKGROUND OF THE INVENTION
The present invention relates to substituted phenolic thioethers, sulfoxides, and disulfides and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful, for example, as anti-inflammatory and anti-allergy
FIELD OF THE INVENTION
The present invention relates to novel conjugated forms of pharmacologically active agents, and methods for the preparation and use thereof. In a particular aspect of the invention, methods are provided for simultaneously treating a pathological condition with a
The present invention relates to the novel method of treating inflammation in mammals by administering the synergistic combination of a non-steroidal agent having anti-inflammatory activity and bis-(2-pyridyl-1-oxide) disulfide and/or at least one metal salt of bis-(2-pyridyl-1-oxide) disulfide and
INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED AS A TEXT FILE VIA THE OFFICE ELECTRONIC FILING SYSTEM (EFS-WEB)
The Sequence Listing associated with this application is provided in text format in lieu of a paper copy, and is hereby incorporated by reference into the specification. The name of the
INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED AS A TEXT FILE VIA THE OFFICE ELECTRONIC FILING SYSTEM (EFS-WEB)
The Sequence Listing associated with this application is provided in text format in lieu of a paper copy, and is hereby incorporated by reference into the specification. The name of the
FIELD OF THE INVENTION
This invention relates to a method for treating inflammatory gastrointestinal diseases, and will have application to a method for treating inflammatory bowel disease. The method involves administering effective amounts of a disulfide or thiol-containing compound to a patient
SEQUENCE STATEMENT
Incorporated by reference herein in its entirety is the Sequence Listing entitled "G18U10C0390PUS_ST25," created Oct. 29, 2018, size of 5 kilobyte.
BACKGROUND
1. Field of the Invention
The prevent invention relates to a gene/carrier complex for preventing or treating inflammatory
FIELD OF THE INVENTION
The present invention relates to sulfide and disulfide compounds; compositions comprising the sulfide or disulfide compounds; and methods for treating or preventing a disease or disorder, for example, cardiovascular disease, dyslipidemia; dyslipoproteinemia; a disorder of
BACKGROUND OF THE INVENTION
The teachings of all of the references cited herein are incorporated in their entirety herein by reference.
Cytokines are soluble proteins that influence the growth and differentiation of many cell types. Their receptors are composed of one or more integral membrane
BACKGROUND OF THE INVENTION
1. Field of the Invention (Technical Field)
This invention relates to a method and composition for radiolabeling monoclonal antibodies against stage specific embryonic antigen-1 with the radioisotope technetium-99m, and further providing for use of the radiolabeled
BACKGROUND OF THE INVENTION
The present invention relates to the novel method of treating inflammation in mammals by administering the synergistic combination of a non-steroidal agent having antiinflammatory activity and at least one metal salt of bis-2-pyridyl-1-oxide) disulfide and to novel
1. BACKGROUND OF THE INVENTION
1.1 Field of the Invention
The present invention relates generally to products that are useful for personal care: the maintenance of personal appearance and good health, and the minor treatments that do not require professional health care. The present invention also
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to conjugates of tumor specific antibodies with cytotoxic compounds. The preferred conjugates contain maytansinoid compounds linked to an anti-integrin antibody by a disulfide linkage.
2. Background of the Invention
There