OSA patients without erectile dysfunction (ED).

OSA patients with erectile dysfunction diagnosis who are randomly allocated to not receive continuous positive airway pressure (CPAP).

OSA patients with erectile dysfunction diagnosis who are randomly allocated to receive CPAP.

Obstructive Sleep Apnea

Continuous positive airway pressure treatment for patients randomized to CPAP treatment group. Treatment duration: 3 months.

Continuous positive airway pressure

Hospital Arnau de Vilanova. IRB Lleida. CIBERes

The Impact of Obstructive Sleep Apnea in Erectile Dysfunction

Effect of 3-months CPAP treatment on the changes in the International Index Erectile Function score of patients with Erectile Dysfunction.

Compare the psychological profile of patients with OSA with and without erectile dysfunction in order to detect psychological distress associated with the risk of developing erectile dysfunction, using SEAR score. Evaluate the impact of CPAP treatment on the change in SEAR score after 3 months.

Compare the secretion profile of sex hormones related to control erectile function in a group of patients with syndrome of obstructive sleep apnea with and without erectile dysfunction. Evaluate the impact of CPAP treatment on the change in the sexual hormone profile after 3 months. All hormones measured in blood samples by means of Radioimmunoassay.

Determine the profile of synthesis of different biomarkers related to endothelial dysfunction and cardiovascular disorder associated to obstructive sleep apnea and its relation to the risk of developing erectile dysfunction. Evaluate the impact of CPAP treatment on the changes in endothelial dysfunction biomarkers after 3 months. All markers measured in blood samples by means of Radioimmunoassay.

Ferran Barbe

Head of Respiratory Medicine at Hospital Universitari Arnau de Vilanova

Sociedad Española de Neumología y Cirugía Torácica

Exercise in room air (normoxia). Sildenafil

Exercise in hypoxic air (reduced O2 concentration) that simulates 2500m elevation for 30-40 minutes with Sildenafil. Placebo

Altitude

Hypoxia

Sildenafil

Exercise

The placebo pill was compounded by McDonalds Pharmacy.

Placebo

Sildenafil from Pfizer, compounded by McDonalds Pharmacy.

University of British Columbia - Environmental Physiology Laboratory

Endurance Performance at Altitude

Ergogenic Effect of PDE-5 Inhibitors at Moderate Altitude

Performance is measured as the mean power output achieved during the time trial task.

PAP is measured in mmHg at the tricuspid jet.

Michael Koehle

Dr. Michael Koehle

University of British Columbia

Impotence

Prostatic Neoplasms

Sildenafil (Viagra) 50 mg - PO QHS for 12 months beginning the first evening they return home from surgical hospital stay PLUS Post-NSRRP hyperbaric oxygen therapy (90 minutes of 100% oxygen at 2.2ATA (equivalent to the pressure exerted at a depth of approximately 40 feet below sea level). There will be 5 or 10 treatments. The full treatment cycle will be completed within 2 weeks.

Sildenafil therapy plus post-NSRRP HBO2T

Sildenafil (Viagra)50 mg - PO QHS for 12 months beginning the first evening they return home from surgical hospital stay PLUS Post-NSRRP sham hyperbaric oxygen therapy - 90 minutes at 2.2ATA but instead of 100% oxygen, they will receive air administered via the oxygen hoods, as if they were being administered oxygen. Participants in this group will receive 5 or 10 sham treatment sessions. Full treatment cycle will be completed within 2 weeks.

erectile dysfunction/hypoxia

The Impact of Obstructive Sleep Apnea in Erectile Dysfunction

Endurance Performance at Altitude

Can Hyperbaric Oxygen Improve Erectile Function Following Surgery for Prostate Cancer

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