Ingredients: Canola meal, seaweed, wheat, glucose, Vitamin D and lactic acid bacteria

Ingredients: Rye flour, water, iodized salt, brown sugar

Glucose Metabolism

Metabolic Syndrome

Gut Microbiota

A daily sachet with 5 gram FCS-granulate for 6 weeks

Fermented canola-seaweed

A daily sachet with 5 gram rye cereal for 6 weeks

Placebo

University of Copenhagen

The SIMBA Project - The Effect of a Prebiotic Supplement on Glucose Metabolism and Gut Microbiota in Obese Adults

The SIMBA Project - The Effect of a Prebiotic Supplement on Glucose Metabolism and Gut Microbiota

2 hour post oral glucose tolerance test glucose measurement in blood (mmol/L)

fasting measurement of blood glycated hemoglobin (%)

Fasting measurement of blood glucose (mmol/L)

Measurement of blood glucose 30 min after OGTT (mmol/L)

Measured as part of the OGTT. Plasma glucose (mmol/l). Plasma insulin - fasting (pmol/l)

Measurements of total and HDL cholesterol (mmol/L) and triglycerides (mmol/L)

Blood measurements of C-Reactive Protein (mg/L)

Blood measurements of Interleukin-6 (pg/mL)

Measured using blood metabolomic measurements of amino acids, lipids, and other small metabolites (umol/L)

Measured using a Tanita body composition analyser. Body weight in kilograms

Measured using a Tanita body composition analyser. Fat free mass and Body fat mass in kilograms used to calculate body fat percentage.

Continuous glucose monitor from Abbott is worn for 14 days in each period providing glucose measurements continuously (mmol/L)

Alanine transaminase (ALAT) (U/L), Aspartate transaminase (ASAT) (U/L)

Mads Vendelbo Lind

Post doc

FermBiotics ApS

The participants will be randomized to the Fermented Canola-Seaweed supplement or control and are expected to consume one sachet (5 grams) of either every day for 6 weeks

The randomization sequence will be done by an investigator without contact to the participants. The personnel conducting the study will allocate participants to the sequence of intervention using a list of participant identification numbers matched with allocated sequences. The participants will be blinded to the intervention and blinding of the allocation sequence will be present for investigators during sample analysis and initial data analysis

Daily consumption of 30 g of raw, fresh, broccoli sprouts, not cooked, during 10 weeks (70 days), followed by other 90 days of no ingestion of broccoli sprouts

Obesity

Inflammation

Broccoli sprouts

Effects of the Consumption of Broccoli Sprouts in Overweight Subjects

Plasma levels of IL-6 measured at days 0, 70, 90 and 160 days of intervention

Plasma levels of C-reactive protein measured at days 0, 70, 90 and 160 days of intervention

24 h-urine levels of glucosinolates and their metabolites measured by UHPLC-MS/MS

Débora Villaño

Proffesor

Universidad Católica San Antonio de Murcia

National Research Council, Spain

The intervention consisted on a 10-week period which included daily consumption of a portion (30 g) of raw, fresh broccoli sprouts. After the intervention period, a follow-up recovery period for all subjects continued for other 90 days with no ingestion of broccoli sprouts.

Scaling and root planning with ultrasonic scalar

Scaling and root planing was done with ultrasonic scalar. It was followed by gum massaging with 0.32gm salt in 5ml mustard oil for 5min, twice daily for 90 days.

Chronic Periodontitis

Scaling and root planning done with ultrasonic scalar with reinforcement of oral hygiene measures and follow up for 90 days.

SCALING AND ROOT PLANING (SRP)

MUSTARD OIL AND SALT MASSAGE WITH SRP

Govt. College of Dentistry Indore, M.P. India

To Study the Beneficial Effect of Mustard Oil and Salt Massaging With Oral Prophylaxis in Patients With Gum Diseases

To Assess the Efficacy of Mustard Oil and Salt Massage as an Adjunct to Scaling and Root Planing in Patients With Chronic Periodontitis: A Clinical Study

Interdental papilla of each teeth in checked

Dr. Trishna Mhapsekar

Government College of Dentistry, Indore

Four x 100g portions of Beneforte broccoli will be consumed each week for twelve weeks, on top of the participants habitual diet.

Four x 100g portions of Parthenon broccoli will be consumed each week for twelve weeks, on top of the participants habitual diet.

Cardiovascular Diseases

Four x 100g portions of Beneforte broccoli will be consumed each week for twelve weeks, on top of the participants habitual diet

Beneforte broccoli

Four x 100g portions of Parthenon broccoli will be consumed each week for twelve weeks, on top of the participants habitual diet

Parthenon Broccoli

University of Reading

Institute of Food Research

Broccoli and Vascular Health Study

The LDL cholesterol concentration (mmol/L) will be measured before and after a 12 week intervention with broccoli, using a Instrumentation Laboratories kit for use on an ILAB auto analyser.

The clinical biomarkers include, hs-CRP (mg/L), NEFAs(mg/dL), Plasma NO(umol/L), hs-IL6(pg/mL), TNF-α(pg/mL), ox LDL(umol/L), IL-1beta(pg/L), PCOOH(pmols/L), F-2 isoprostanes (mg/mL/mg creatine) and 8-OHdG (ng/mL).
The effect of the intervention on arterial stiffness on a sub section of the cohort (Reading cohort)will also be measured. The first measurement will be Pulse wave velocity (m/sec); the 2nd measurement will be Laser Doppler Imaging with iontophoresis (perfusion units(area under the blood flow.time curve)).

DNA samples from all participants will be genotyped for PAPOLG (NM_022894.3) rs11687951, rs28459296 and rs7579240 and GSTM1 genotype using predesigned Invitrogen TaqMan® Assays according to manufacturers' instructions.

glucosinolate/obezita

The SIMBA Project - The Effect of a Prebiotic Supplement on Glucose Metabolism and Gut Microbiota in Obese Adults

Effects of the Consumption of Broccoli Sprouts in Overweight Subjects

To Study the Beneficial Effect of Mustard Oil and Salt Massaging With Oral Prophylaxis in Patients With Gum Diseases

Broccoli and Vascular Health Study

Nejúplnější databáze léčivých bylin podložená vědou