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12 Výsledek
Histone deacetylase inhibitors
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Přihlášení Registrace
TECHNICAL FIELD
This invention relates to enzyme inhibitors, and more particularly to histone deacetylase inhibitors.
BACKGROUND
DNA in the nucleus of the cell exists as a hierarchy of compacted chromatin structures. The basic repeating unit in chromatin is the nucleosome. The nucleosome consists of
Histone deacetylase inhibitors based on trihalomethylcarbonyl compounds
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD
This invention relates to trihalomethylcarbonyl compounds, and more particularly to trihalomethylcarbonyl compounds that are histone deacetylase inhibitors.
BACKGROUND
DNA in the nucleus of the cell exists as a hierarchy of compacted chromatin structures. The basic repeating unit in
Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD
This invention relates to alpha-ketoepoxide compounds, and more particularly to alpha-ketoepoxide compounds that are histone deacetylase inhibitors.
BACKGROUND
DNA in the nucleus of the cell exists as a hierarchy of compacted chromatin structures. The basic repeating unit in
Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD
This invention relates to alpha-ketoepoxide compounds, and more particularly to alpha-ketoepoxide compounds that are histone deacetylase inhibitors.
BACKGROUND
DNA in the nucleus of the cell exists as a hierarchy of compacted chromatin structures. The basic repeating unit in
Histone deacetylase inhibitors based on alpha-chalcogenmethylcarbonyl compounds
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD
This invention relates to alpha-chalcogenmethylcarbonyl compounds, and more particularly to alpha-chalcogenmethylcarbonyl compounds that are histone deacetylase inhibitors.
BACKGROUND
DNA in the nucleus of the cell exists as a hierarchy of compacted chromatin structures. The basic
Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD
This invention relates to alpha-ketoepoxide compounds, and more particularly to alpha-ketoepoxide compounds that are histone deacetylase inhibitors.
BACKGROUND
DNA in the nucleus of the cell exists as a hierarchy of compacted chromatin structures. The basic repeating unit in
Treatments for spinal muscular atrophy
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Přihlášení Registrace
BACKGROUND OF THE INVENTION
Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by degeneration of spinal cord anterior horn cells, which lead to muscular paralysis with muscular atrophy. SMA patients are afflicted to varying degrees of severity and are
Activators of class I histone deacetlyases (HDACs) and uses thereof
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The field of the invention pertains to activators of class I histone deacetylases and their uses in the treatment of neurological disorders.
BACKGROUND OF THE INVENTION
In a variety of neurodegenerative disorders such as ischemia and Alzheimer's disease (Hayashi et al.,
Compounds for the inhibition of histone deacetylase
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The present invention relates to novel compounds which are useful as the agents for prevention or treatment of diseases associated with histone deacetylase (HDAC), in particular, tumor or cell proliferative diseases. They also can be used as the agents for enhancing the
Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The present invention relates to novel cinamic compounds which are useful as agents for the prevention or treatment of diseases associated with histone deacetylase (HDAC). They also can be used as agents for enhancing the neurite outgrowth. In particular, they can be used as
Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The present invention relates to novel cinamic compounds which are useful as agents for the prevention or treatment of diseases associated with histone deacetylase (HDAC). They also can be used as agents for enhancing the neurite outgrowth. In particular, they can be used as
Modulation of epigenetic stress response
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Přihlášení Registrace
TECHNICAL FIELD
The invention relates to the field of medical diagnostics and therapeutics, and more particularly to methods for recognizing and treating biological phenomena that significantly exacerbate disease via epigenetic responses to stress, and for identifying molecules that may be
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