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Strana 1 z 200 Výsledek
Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury.
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Přihlášení Registrace
BACKGROUND
Valproic acid (VPA) is a histone deacetylase inhibitor that may decrease cellular metabolic needs following traumatic injury. We hypothesized that VPA may have beneficial effects in preventing or reducing the cellular and metabolic sequelae of ischemia-reperfusion
Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Pharmacological histone deacetylase (HDAC) inhibitors, such as known anticonvulsant valproic acid (VPA), demonstrate cytoprotective effects and increase acetylation of nuclear histones, promoting transcriptional activation of deregulated genes. Therefore, we examined protective effects of
Valproic acid prevents hemorrhage-associated lethality and affects the acetylation pattern of cardiac histones.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Pharmacological inhibitors of histone deacetylases (HDAC) demonstrate cytoprotective effects both in vitro and in vivo. In this study, we investigated whether valproic acid (VPA), a known mood stabilizer and anticonvulsant with HDAC-inhibiting activity, improves survival following otherwise lethal
Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice.
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Přihlášení Registrace
OBJECTIVE
To investigate the consequences of histone deacetylase inhibition by histone deacetylase inhibitor valproic acid and IκB kinase/nuclear factor-κB signaling blockade by IκB kinase inhibitor BAY11-7082 on (microvascular) endothelial cell behavior in vitro as well as in mice subjected to
Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
DNA transcription is regulated in part by acetylation of nuclear histones, controlled by 2 groups of enzymes: histone deacetylases (HDAC) and histone acetyl transferases (HAT). We have shown previously that hemorrhage and resuscitation are associated with HDAC/HAT imbalance, which
Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
We have previously shown that resuscitation with fresh frozen plasma (FFP) in a large animal model of traumatic brain injury (TBI) and hemorrhagic shock (HS) decreases the size of the brain lesion, and that addition of a histone deacetylase inhibitor, valproic acid (VPA), provides
Comparative analysis of isoform-specific and non-selective histone deacetylase inhibitors in attenuating the intestinal damage after hemorrhagic shock.
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Přihlášení Registrace
Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
We recently discovered that Tubastatin-A, a histone deacetylase (HDAC6) inhibitor, can improve survival in a rodent model of hemorrhagic shock (HS), but mechanisms remain poorly defined. In this study, we investigated whether Tubastatin-A could protect intestinal tight junction (TJ) in HS.
In an
Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cells.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
We have previously demonstrated that treatment with histone deacetylase inhibitors (HDACI), such as valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA), can improve survival after hemorrhagic shock in animal models. Hemorrhage results in hypoacetylation of proteins which is
Pharmacokinetics and Acute Toxicity of a Histone Deacetylase Inhibitor, Scriptaid, and Its Neuroprotective Effects in Mice After Intracranial Hemorrhage.
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Přihlášení Registrace
Selective inhibition of histone deacetylase 6 promotes survival in a rat model of hemorrhagic shock.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Hemorrhage is the leading cause of preventable trauma-related deaths. We have previously shown that treatment with Tubastatin A (Tub A), a histone deacetylase 6 (HDAC6) inhibitor, can improve survival in a rodent model of septic shock. The aims of the present study were to determine
Cardiac histones are substrates of histone deacetylase activity in hemorrhagic shock and resuscitation.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
DNA transcription is regulated, in part, by acetylation of nuclear histones that are controlled by 2 groups of enzymes: histone deacetylases (HDAC) and histone acetyl transferases (HAT). Whether an imbalance in HDAC/HAT system plays a role in hemorrhage/resuscitation is unknown. The goals
Histone deacetylase inhibitors: Isoform selectivity improves survival in a hemorrhagic shock model.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Hemorrhage is a leading preventable cause of death. Nonselective histone deacetylase inhibitors (HDACIs), such as valproic acid (VPA), have been shown to improve outcomes in hemorrhagic shock (HS). The HDACs can be divided into four functional classes (I, IIa/IIb, III, and IV). Classes I,
Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
We have demonstrated that valproic acid (VPA), a histone deacetylase inhibitor (HDACI), can improve animal survival after hemorrhagic shock, and protect neurons from hypoxia-induced apoptosis. This study investigated whether VPA treatment works through the c-Jun N-terminal kinase
Impact of resuscitation strategies on the acetylation status of cardiac histones in a swine model of hemorrhage.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Chromatin remodeling through histone acetylation is a key control mechanism in gene transcription. We have shown previously that fluid resuscitation in rodents is coupled with highly structured post-translational modifications of cardiac histones. The current experiment was performed to
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