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huperzine a/ischemie
Odkaz je uložen do schránky
Strana 1 z 16 Výsledek
Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Huperzine A, a reversible and selective acetylcholinesterase (AChE) inhibitor, has been reported to display neuroprotective properties. The present study investigated the protective effects of huperzine A in a rat model of transient focal cerebral ischemia created by middle cerebral artery occlusion
Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The protective effects of huperzine A on transient global ischemia in gerbils were investigated. Five min of global ischemia in gerbils results in working memory impairments shown by increased escape latency in a water maze and reduced time spent in the target quadrant. These signs of dysfunction
The protective effect of huperzine A against hepatic ischemia reperfusion injury in mice.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Nowadays, hepatic ischemia reperfusion (HI/R) injury is regarded as a serious concern in clinical practices. Huperzine A (HupA) is an alkaloid isolated from the Chinese folk medicine huperzia serrate, which has possessed diverse pharmacological actions.
METHODS
A mouse model of HI/R was
Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Hepatic ischemia reperfusion (HI/R) injury may occur during liver transplantation and remains a serious concern in clinical practice. Huperzine A (HupA), an alkaloid isolated from the Chinese traditional medicine Huperzia serrata, has been demonstrated to possess anti‑oxidative and anti‑apoptotic
Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
This study is to investigate the effects of huperzine A on memory deficits, neuronal damage and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice, as well as the potential downstream signaling pathway. Bilateral common carotid occlusion (BCCAo) combined with
Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The protective effects of huperzine A, a novel acetylcholinesterase inhibitor, on hypoxic-ischemic (HI) brain injury were investigated in neonatal rats. A unilateral HI brain injury was produced by the ligation of left common carotid artery followed by 1 h hypoxia with 7.7% oxygen in 7-day-old rat
AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
We recently reported that the expression of the synaptic form of acetylcholinesterase (AChE) is induced during apoptosis in various cell types in vitro. Here, we provide evidence to confirm that AChE is expressed during ischemia-reperfusion (I/R)-induced apoptosis in vivo. Renal I/R is a major cause
Assessment of the neuroprotective effects of the acetylcholinesterase inhibitor Huperzine A in an experimental spinal cord trauma model.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Spinal cord injury is nowadays still a challenging disease, and a treatment option aimed at the primary site of injury does not currently exist. Therefore, the management of acute spinal cord injury has recently focused on the reasons behind the aggravation of the initial insult through
Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The effects of (-)-huperzine A, a promising therapeutic agent for Alzheimer's disease, on learning behavior and on alterations of the cholinergic system, the oxygen free radicals and energy metabolites induced by permanent bilateral ligation of the common carotid arteries were investigated in rats.
Huperzine A for Alzheimer's disease.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND
Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the
Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Mitochondrial dysfunction has been proved to contribute to ischemia-induced brain damage. In this study, which used a rat middle cerebral artery occlusion (MCAO) model, the protective effects of huperzine A (HupA) against mitochondrial dysfunction and brain damage were investigated. MCAO for 45 min
Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Post-stroke depression (PSD) is the most common mood disorder following a stroke, and is also the main factor limiting recovery and rehabilitation in stroke patients. The present study was aimed to investigate whether Huperzine A (HupA) has antidepressant-like activity in a rat model of PSD, which
The NMDA receptor ion channel: a site for binding of Huperzine A.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Huperzine A (HUP-A), first isolated from the Chinese club moss Huperzia serrata, is a potent, reversible and selective inhibitor of acetylcholinesterase (AChE) over butyrylcholinesterase (BChE) (Life Sci. 54: 991-997). Because HUP-A has been shown to penetrate the blood-brain barrier, is more stable
Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Huperzine A (HupA), isolated from Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase. It has been found to reverse or attenuate cognitive deficits in a broad range of animal models. Clinical trials in China have demonstrated that HupA
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase(AChE). Compared with tacrine, donepezil, and rivastigmine, HupA has better penetration through the blood-brain barrier, higher oral
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