Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The Sequence Listing submitted Dec. 4, 2012 as a text file named "MUSC.sub.--10.sub.--8403_ST25.txt," created on Dec. 3, 2012, and having a size of 1,266 bytes is hereby incorporated by reference.
BACKGROUND
An important structural event following myocardial infarction (MI) is LV remodeling which
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION
Cysteine proteases, such as cathepsins B, L, S, and O.sub.2, have been implicated in a number of diseases, including cancer metastasis and invasion (Clin. Exp. Metastasis 1992, 10, 145-155; Cancer Metastasis Rev. 1990, 9, 333-352), arthritis (Int. J. Biochem. 1993, 25,
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
This is a national stage entry of PCT/EP2008/001009, filed Feb. 11, 2008, which claims priority to EP 07002903.8, filed Feb. 12, 2007, all of which are incorporated herein by reference.
The subject of the present invention is, in the most general aspect, the therapeutic application of the Kazal-type
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF INVENTION
Cysteine proteases, such as cathepsins B, H, K, L, S, and O.sub.2, containing a highly reactive cysteine residue with a free thiol group at the active site have been known as playing an important role in certain conditions distinguished by aberrant protein turnover such as:
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists of
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists of
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists of
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION
Apoptosis, or programmed cell death (PCD), is a genetically regulated mechanism with a central role in both metazoan development and homeostasis. (Raff, 1992; Steller, 1995). The cell death machinery is conserved throughout evolution (Vaux et al., 1994) and is composed of
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists of
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
1. FIELD OF THE INVENTION
The present invention relates to compositions and methods useful in the inhibition of apoptosis. Likewise, the present invention relates to methods of treating diseases associated with excessive or unregulated apoptosis.
2. BACKGROUND OF THE INVENTION
Normal development,
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
INCORPORATION BY REFERENCE OF SEQUENCE LISTING PROVIDED ELECTRONICALLY
An electronic version of the Sequence Listing is filed herewith, the contents of which are incorporated by reference in their entirety. The electronic file was created on May 9, 2014, is 2,308 kilobytes in size, and titled
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a novel sulfonamide derivative. More particularly, it relates to a novel sulfonamide derivative or a salt thereof which shows a strong inhibitory activity against cysteine protease such as calpain, cathepsin B,
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION
1. Field
The present invention relates to novel nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel nitrile derivatives of formula (I)
2. Description
Cysteine proteases have been viewed as lysosomal mediators of
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION
Cysteine proteases have been viewed as lysosomal mediators of terminal protein degradation. Several newly discovered members of this enzyme class, however, are regulated proteases with limited tissue expression, which implies specific roles in cellular physiology and thus
Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION
The present invention relates to novel beta-amino acid nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel beta-amino acid nitrile derivatives of formula (I) ##STR1##
wherein R.sup.1 represents hydrogen, aryl,
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