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lysin/zánět

Odkaz je uložen do schránky
ČlánkyKlinické testyPatenty
Strana 1 z 40 Výsledek

Extracellular beta-lysin and muramidase in body fluids and inflammatory exudates.

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Přihlášení Registrace

Increased serum antibacterial activity after turpentine-induced acute inflammation.

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Přihlášení Registrace
An acute inflammatory response was induced in rabbits by an intramuscular injection of turpentine. After this injection serial serum samples were obtained and serum haptoglobin levels were monitored. In addition, increased antibacterial activity was measured using a viable plate and photometric

Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
By virtue of its binding to cyclophilin, the cellular receptor for cyclosporine (CsA), we could identify a new compound D-43787 [N-[(1-tert-butyloxycarbonyl)-indolin-2-(S)-carbonyl]-indolin-2-(S)-carbonacid-[N-epsilon-benzyloxycarbonyl)-2-(S)-lysin methylester]-amide] exhibiting immunomodulating
BACKGROUND Horses commonly suffer from chronic respiratory disease and are also used in large animal models of spontaneous or induced airway inflammation. The anti-inflammatory properties of curcumin are largely described but its low bioavailability precludes its clinical use. NDS27, a lysin salt of

[The level of beta-lysines in serum as an indicator of activity of the inflammatory process].

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
A follow-up of patients with various diseases has revealed a close correlation between the 2-3-fold increase of the blood serum beta-lysins vs. the norm and the development of an acute inflammatory reaction, no matter what its etiology or localization. A high diagnostic informativeness of this

[Differential effects of morphine and non-steroidal anti-inflammatory drugs on somatic and visceral pain in rats].

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Přihlášení Registrace
We studied the differential effects of morphine and non-steroidal anti-inflammatory drug (NSAIDs) on behavioral responses to tail-flick (TF) and colorectal distension (CD) in rats. Animals were randomly divided into three groups; morphine groups (4 mg.kg-1), flurbiprofen axetil groups (30 mg.kg-1)
NK-lysin (NKL) is a cationic host defense peptide that plays an important role in host immune responses against various pathogens. However, the immunomodulatory activity of NKL in fishes is rarely investigated. In this study, we characterized a cDNA sequence encoding an NK-lysin homolog (BpNKL) from
Immunological investigation of 193 patients with uncomplicated lymphedema and lymphedema complicated with erysepalas inflammation registered in the patients with inflammation high levels of antigen-nonspecific circulating immune complexes, beta-lysins, alpha1-antitripsin, serum IgE and IgM in the

Release of beta-lysin from platelets caused by antigen-antibody complexes, purified enzymes, and platelet-aggregating substances.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
The release of beta-lysin, which followed the intravenous injection of antigen-antibody complexes, did not take place when these complexes were added to citrated whole blood but did occur in heparinized blood. beta-Lysin release in heparinized blood was inhibited by citrate but were reversed by the

Evaluation of the Immunomodulatory Activity of the Chicken NK-Lysin-Derived Peptide cNK-2.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Chicken NK-lysin (cNK-lysin), the chicken homologue of human granulysin, is a cationic amphiphilic antimicrobial peptide (AMP) that is produced by cytotoxic T cells and natural killer cells. We previously demonstrated that cNK-lysin and cNK-2, a synthetic peptide incorporating the core α-helical
Staphylococcus aureus is the main pathogen that causes skin and skin structure infections and is able to survive and persist in keratinocytes of the epidermis. Since the evolution of multidrug-resistant bacteria, the use of phages and their lysins has presented a promising alternative approach to

Advanced engineering of third-generation lysins and formulation strategies for clinical applications

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Přihlášení Registrace
One of the possible solutions for the current antibiotic resistance crisis may be found in (often bacteriophage-derived) peptidoglycan hydrolases. The first clinical trials of these natural enzymes, coined here as first-generation lysins, are currently ongoing. Moving beyond natural endolysins with
Staphylococcus aureus (S. aureus) is a common and dangerous pathogen that causes various infectious diseases. Skin damage, such as burn wounds, are at high risk of Staphylococcus aureus colonization and infection, which increases morbidity and mortality. The phage lysin LysGH15 exhibits highly

LysGH15 kills Staphylococcus aureus without being affected by the humoral immune response or inducing inflammation.

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Přihlášení Registrace
The lysin LysGH15, derived from the staphylococcal phage GH15, exhibits a wide lytic spectrum and highly efficient lytic activity against methicillin-resistant Staphylococcus aureus (MRSA). Here, we found that LysGH15 did not induce resistance in MRSA or methicillin-sensitive S. aureus (MSSA)

Chimeric phage lysins act synergistically with lysostaphin to kill mastitis-causing Staphylococcus aureus in murine mammary glands.

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
Staphylococci cause bovine mastitis, with Staphylococcus aureus being responsible for the majority of the mastitis-based losses to the dairy industry (up to $2 billion/annum). Treatment is primarily with antibiotics, which are often ineffective and potentially contribute to resistance development.
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