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non-alcoholic fatty liver disease/obezita

Odkaz je uložen do schránky
Strana 1 z 82 Výsledek

Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (NASH)

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
REFERENCE TO SEQUENCE LISTING The present application is filed with a Sequence Listing in Electronic format. The Sequence Listing is provided as a file entitled "2014-02-03 Sequence list--CHMC38.001A.txt", created Feb. 3, 2014, which is approximately 4 kb in size. The information in the electronic

Treatment of obesity

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with

Anti-obesity product and its method of preparation

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD The present invention relates to compositions comprising one or more anthraquinones for use in the treatment of obesity, metabolic disease, or liver disease. More particularly it relates to a plant extract fraction rich in anthraquinones including both anthraquinone glycosides (major

Anti-obesity product and its method of preparation

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD The present invention relates to compositions comprising one or more anthraquinones for use in the treatment of obesity, metabolic disease, or liver disease. More particularly it relates to a plant extract fraction rich in anthraquinones including both anthraquinone glycosides (major

Nutritional composition

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD The present invention relates to a nutrient composition (nutritional composition) having lipid metabolism-improving action. The nutrient composition highly effectively contributes to decrease of neutral lipids (triglycerides). The nutrient composition is expected to offer

Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H.sub.3 antagonists

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION The present invention relates to heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H.sub.3 antagonists. The invention also relates to pharmaceutical compositions comprising said compounds and their use in treating inflammatory diseases,

Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H.sub.3 antagonists

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION The present invention relates to heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H.sub.3 antagonists. The invention also relates to pharmaceutical compositions comprising said compounds and their use in treating inflammatory diseases,

Carbon-linked substituted piperidines and derivatives thereof useful as histamine H.sub.3 antagonists

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION The present invention relates to carbon-linked substituted piperidines and derivatives thereof useful as histamine H.sub.3 antagonists. The invention also relates to pharmaceutical compositions comprising said compounds and their use in treating inflammatory diseases, allergic

N-terminal modified FGF21 compounds

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THIS INVENTION The present invention relates to Fibroblast Growth Factor 21 (FGF21), more in particular to derivatives of FGF21 compounds having a modifying group of the formula A-B-C-D- covalently attached. The invention also relates to novel FGF21 analogues, as well as to the

Co-agonists of the glucagon and GLP-1 receptors

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION (1) Field of the Invention The present invention relates to peptide analogs of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the

Compounds for the treatment of metabolic disorders

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION Diabetes mellitus is a major cause of morbidity and mortality. Chronically elevated blood glucose leads to debilitating complications: nephropathy, often necessitating dialysis or renal transplant; peripheral neuropathy; retinopathy leading to blindness; ulceration of the

Biaryl derivatives as GPR120 agonists

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD The present invention relates to novel biaryl derivatives as GPR120 agonists, a method for preparing the same, a pharmaceutical composition comprising the same as active components and use thereof. Herein a GPR120 agonist means a compound which can be effectively used for preventing

Thioaryl derivatives as GPR120 agonists

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
TECHNICAL FIELD The present invention relates to novel thioaryl derivatives as GPR120 agonists, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. Herein a GPR120 agonist means a compound which can be effectively used for preventing or treating

Methods for treating bone disorders by characterizing and restoring mammalian bacterial microbiota

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
FIELD OF THE INVENTION The present invention relates to characterizing changes in mammalian gastrointestinal microbiota associated with antibiotic treatment and various disease conditions (such as obesity, metabolic syndrome, insulin-deficiency or insulin-resistance related disorders, glucose

Role of p62 in aging-related disease

Články mohou překládat pouze registrovaní uživatelé
Přihlášení Registrace
BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to a method of detecting the formation of inclusion bodies such as sequestosomes. The invention also relates to a method of detecting inclusion bodies in neurodegenerative diseases. The invention further relates to a method
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