phytohemagglutinin/atrofie

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A specific enzyme defect in gyrate atrophy.

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Přihlášení Registrace

To establish the enzyme defect in gyrate atrophy, we measured the activity of ornithine aminotransferase in phytohemagglutinin stimulated lymphocytes in a patient with gyrate atrophy, her daughter, and three normal controls. The patient's cells had no detectable ornithine aminotransferase activity

Gyrate atrophy of the choroid and retina: deficiency of ornithine aminotransferase in transformed lymphocytes.

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Přihlášení Registrace

Gyrate atrophy of the choroid and retina is an inherited form of chorioretinal degeneration associated with hyperornithinemia. We measured the activity of ornithine aminotransferase (L-ornithine:2-oxo-acid aminotransferase, EC 2.6.1.13) in phytohemagglutinin-stimulated lymphocytes of a patient with

Hyperornithinemia with gyrate atrophy of the choroid and retina: a disturbance in de novo formation of proline.

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Přihlášení Registrace

Two patients with hyperornithinemia and gyrate atrophy of the choroid and retina, the first report in Japan, were described. Serum ornithine was increased 10- to 15-fold and serum lysine was slightly decreased in the affected patients. Urinary excretion of ornithine was also markedly increased.

[Effects of urologic surgery on lymphocyte blastogenic response to phytohemagglutinin].

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Přihlášení Registrace

In order to study the effect of urological surgery on the defence system, we have evaluated the postoperative evolution of the lymphocyte blastogenic response to phytohemagglutinin (PHA) in 45 patients. 25 of them were subjected to a transurethral resection (TUR) of a vesical tumour, 10 to a

Early swelling response to phytohemagglutinin is lower in older toads.

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Přihlášení Registrace

The effects of age on performance of life-history traits are diverse, but a common outcome is senescence, an irreversible deterioration of physical and physiological capabilities of older individuals. Immune response is potentially bound to senescence. However, little is known about immune response

Mitochondrial cardiomyopathy and scapuloperoneal spinal muscular atrophy in a child.

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A 14-year old boy was admitted for signs of heart failure and scapuloperoneal muscle weakness. He fulfilled the clinical, functional and diagnostic criteria for dilated cardiomyopathy. There was also a moderate increase in pulmonary vascular resistance. The immunohistochemical examination of the

Mechanisms of lectin (phytohemagglutinin)-induced growth in small intestinal epithelial cells.

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Přihlášení Registrace

OBJECTIVE The lectin phytohemagglutinin is a mitogen for intestinal epithelial cells in vivo. The mechanisms of action are unknown and were therefore analyzed in vitro. METHODS Human (Intestine-407) and rat (IEC-6; IEC-18) intestinal epithelial cell lines were stimulated with phytohemagglutinin.

Sequential observations of in vitro responses of lymphocytes to phytohemagglutinin in patients receiving gold therapy for rheumatoid arthritis.

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Forty-seven patients receiving gold therapy for rheumatoid arthritis were observed sequentially at 6-monthly intervals. When the disease was in remission, and remained so, the in vitro responses of lymphocytes to phylohemagglutinin stimulation tended to be normal. Improvement in the disease were

Long-term melatonin supplementation does not recover the impairment of natural killer cell activity and lymphocyte proliferation in aging mice.

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Přihlášení Registrace

In this study we evaluated the effect of long-term melatonin (MEL) treatment on the cytotoxic activity and number of natural killer (NK) cells and the proliferative response of spleen lymphocytes to phytohemagglutinin (PHA) or interleukin-2 (IL-2) in old mice. Seventeen-eighteen month-old Balb/c

Reduced immune responsiveness and lymphoid depletion in mice infected with Ehrlichia risticii.

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Přihlášení Registrace

The histopathology of the thymus and spleen and the response of spleen cells to mitogenic stimuli were evaluated in Sprague-Dawley CF-1 mice infected with Ehrlichia risticii. Intraperitoneal injection of 10(4) or 10(6) E. risticii-infected U-937 cells into mice resulted in 100% morbidity and partial

Evidence for direct action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium.

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Přihlášení Registrace

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) acts on selected targets within the immune system to produce a characteristic profile of pathologic responses typified by thymic atrophy, suppressed cellular immunity, and inhibition of antibody production to T-lymphocyte-dependent antigens. Studies in

Natural human IgG inhibits the production of tumor necrosis factor-alpha and interleukin-1 alpha through the Fc portion.

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Přihlášení Registrace

The overproduction of cytokines such as the tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) may cause further deterioration in the already critical condition of patients with shock, sepsis, and acute inflammation. The effectiveness of infusion therapy of natural human

Altered function and membrane properties of lymphocytic leukemia cells. Correlation with clinical stage of disease.

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Přihlášení Registrace

Lymphocytes from the peripheral blood of patients with chronic lymphocytic leukemia (CLL) were examined for the presence of several recognized surface receptors [immunoglobulins, C3 component of complement, and concanavalin A (Con A)] and for structural changes in membrane distribution and dynamics,

Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice.

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Přihlášení Registrace

The age-related decline in immune function, which is thought to be responsible for the increased incidence with age of certain diseases, including cancer, has been attributed primarily to a loss of T-lymphocyte function. As free radical reactions may contribute to cellular deterioration and loss of

Suppression of tumor growth and enhancement of immune status with high levels of dietary vitamin B6 in BALB/c mice.

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Přihlášení Registrace

Effects of dietary vitamin B6 at levels ranging from deficiency to megadoses on the development of herpes simplex virus type 2-transformed (H238) cell-induced tumors and on in vitro responses relating to cell-mediated immunity were examined. Male BALB/cByJ mice (n = 260), 5 weeks of age, were fed

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