pongamia glabra/protizánětlivé

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Anti-inflammatory Flavanones and Flavanols from the Roots of Pongamia pinnata.

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A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned

Anti-inflammatory activity of seed extracts of Pongamia pinnata in rat.

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Pongamia pinnata is a marsh growing Indian tree. Its seeds are used in febrile and inflammatory diseases in Indian system of medicine. Previous preliminary studies with ethanolic seed extract of this plant had exhibited an anti-inflammatory effect in rat. Different solvent fractionated extracts were

Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats.

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In the present study, the anti-inflammatory activity of 70% ethanolic extract of Pongamia pinnata leaves (PLE) in acute, subacute and chronic models of inflammation was assessed in rats. Per os (p.o.) administration of PLE (300, 1000 mg/kg) exhibited significant anti-inflammatory activity in acute

Anti-inflammatory isoflavones and isoflavanones from the roots of Pongamia pinnata (L.) Pierre.

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A phytochemical study on the roots of Pongamia pinnata afforded five new isoflavone and isoflavanone derivatives (1-5), including two previously undescribed phenylisoflavones possessing an 1,2-oxetane ring, along with 21 known compounds (6-26) among which compound 18 is the first time to be isolated

Anti-inflammatory pterocarpanoids from the roots of Pongamia pinnata.

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A phytochemical study on the roots of Pongamia pinnata afforded 11 pterocarpanoids, including three new compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and HRESIMS data. The absolute configurations of the new compounds were assigned via analysis of the

Anti-inflammatory flavone and chalcone derivatives from the roots of Pongamia pinnata (L.) Pierre.

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A phytochemical study on the roots of Pongamia pinnata (L.) Pierre yielded 52 flavonoids, including four previously undescribed flavone and four previously undescribed chalcone derivatives. The structures of the isolated compounds were determined on the basis of the 1D, 2D NMR, and mass

Prevention of arthritis markers in experimental animal and inflammation signalling in macrophage by Karanjin isolated from Pongamia pinnata seed extract.

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Karanjin, the furanoflavonoid reported to possess gastroprotective and anti-diabetic properties, was investigated against experimental arthritis and its molecular signalling in inflammation was explored in macrophages. Karanjin was isolated from hexane extract of Pongamia pinnata seeds and was

Suppression of NF-κB p65 nuclear translocation and tumor necrosis factor-α by Pongamia pinnata seed extract in adjuvant-induced arthritis.

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Pongamia pinnata is a plant known for its therapeutic usage in Indian traditional medicine. Despite the controversy regarding toxic flavonoid and erucic acid content, the seed of this plant is consumed in tribal medicine and its oil is used in Ayurveda to treat psoriasis and arthritis. This study

Pharmacological actions of Pongamia pinnata roots in albino rats.

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Pongamia pinnata root has been advocated in Ayurveda for treatment of various inflammatory and infective conditions including ulcers. Sequential petroleum ether, benzene, chloroform, acetone and ethanolic extracts of P. pinnata roots when administered in the dose of 50 mg/kg, i.p. in rats was found

Anti-inflammation compounds from the seedpods of Pongamia pinnata (L.) Pierre guided by the bioactivity and UPLC-HRESIMS.

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Pongamia pinnata (Linn.) Pierre has anti-inflammatory activity and could significantly decrease serum tumor necrosis factor-α and IL-10 in arthritic rats. Previous research indicated the typical chemical constituent in P. pinnata is furanoflavone. Guided by anti-inflammatory active assay and

Pharmacological actions of Pongamia pinnata seeds--a preliminary study.

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Direct ethanolic and sequential petroleum ether, chloroform, acetone and ethanolic extracts (50-100 mg/kg, i.p.) of P. pinnata seeds given 30-60 min before revealed anti-inflammatory, analgesic and anti-ulcerogenic activities in rats. The activities were present maximum in petroleum ether and

Evaluation of wound healing, anti-microbial and antioxidant potential of Pongamia pinnata in wistar rats.

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OBJECTIVE To investigate wound healing, antimicrobial and antioxidant activity of leaf extract of Pongamia Pinnata. METHODS Methanolic extracts of P. pinnata leaf were studied for wound healing efficiency, and was assessed by the rate of wound contraction, tensile strength, breaking strength,

Medicinal uses, phytochemistry and pharmacology of Pongamia pinnata (L.) Pierre: a review.

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BACKGROUND Pongamia pinnata (L.) Pierre is one of the many plants with diverse medicinal properties where all its parts have been used as traditional medicine in the treatment and prevention of several kinds of ailments in many countries such as for treatment of piles, skin diseases, and

Effects of dextran sulfate, 4-t-butylcyclohexanol, pongamia oil and hesperidin methyl chalcone on inflammatory and vascular responses implicated in rosacea.

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UNASSIGNED Rosacea is a chronic facial skin disorder characterized by inflammation and vascular abnormalities. The pathophysiology of rosacea involves increased activation of the capsaicin receptor, TRPV1, the vascular endothelial growth factor (VEGF) pathway, and cathelicidin LL-37, MMP-9, and

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