The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression. ##STR00001##

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences, P.L.A.

Amine derivative with potassium channel regulatory function, its preparation and use

A sensor is disclosed, for implantation within a blood vessel to monitor a substance in or property of blood. In one embodiment, the sensor detects nitric oxide or a nitric oxide metabolite. In another embodiment, other substances such as glutamate, aspartate, arginine, citrulline, acetylcholine, calcium, potassium, or dopamine are monitored. The sensor may be attached to a support structure such as a stent, guidewire, or catheter. In a further embodiment, a catheter is disclosed that extracts patient fluid to a sensor outside the body for monitoring a substance or property of the patient fluid. Methods are also disclosed.

Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction

Compounds which may be represented by the general formula (I) shown below and in which: R.sub.1 is a group independently selected from among: CHO, --COOH, --CH.sub.2OH R.sub.2 is hydrogen or a linear or branched C.sub.1-C.sub.6 alkyl group R.sub.3 is hydrogen or a halogen group selected from among Cl and Br R.sub.4 is a linear or branched C.sub.3-C.sub.5 alkyl group and the pharmaceutically acceptable salts thereof such as the sodium or potassium salt. The compounds exhibit potent and selective All antagonist activity and are useful for the treatment of any disorders in which elevated synthesis of All or overexpression of the AT.sub.1 receptor may play a primary pathological role, as in the case of arterial hypertension, congestive cardiac insufficiency, platelet aggregation and disorders associated therewith such as for example myocardial and cerebral infarction, renal ischaemia, venous and arterial thrombosis, peripheral vasculopathy, pulmonary hypertension, diabetes mellitus, diabetic neuropathy, glaucoma and diabetic retinopathy. ##STR00001##

Rottapharm S.p.A.

Pyrrole derivatives with angiotensin II antagonist activity

Sodium bicarbonate and potassium bicarbonate are systemic anticoagulants that when administered internally inhibit blood coagulation in man and in warm-blooded animals. As such, they are useful and effective in the treatment and/or prevention of thromboembolic diseases, myocardial infarction or other conditions associated with high risk of thromboembolism. Sodium bicarbonate is especially useful for preventing clotting of ptient's blood during kidney dialysis and for preserving citrated human or animal whole blood and plasma indefinitely under proper storage conditions.

potassium/záhať

Amine derivative with potassium channel regulatory function, its preparation and use

Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction

Pyrrole derivatives with angiotensin II antagonist activity

Prophylaxis and treatment of thromboembolic disorders in man and in warm-blooded animals with bicarbonate salts of alkali metals

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