A method and composition for promoting the healing of an open wound, such as a fresh surgical incision, a decubitus ulcer, or a diabetes ulcer. The method includes applying to the wound a therapeutically effective amount of a composition comprising a protein fragment of tumor necrosis factor .alpha.(TNF-.alpha.) including amino acids 31 through 68 SEQ ID NO.: 1. The composition may be applied topically or injected locally into a wound or ulcer site. A preferred composition includes a carrier medium selected from sterile water, sterile saline, and albumin. Topical formulations are administered as sprays, gels, ointments or salves.

The University of Tennessee Research Corporation

Fragment of TNF-.alpha. for promoting wound healing

The invention provides a total enteral nutritious composition containing proteins, sugars, fats, minerals and vitamins, which improves serum albumin and ameliorates bedsores. The total enteral nutritious composition has a zinc/copper weight ratio of 10-25, and a zinc content of 1.5 mg or greater, a copper content of 0.075-0.15 mg, a sodium content of at least 185 mg, a vitamin B1 content of at least 0.30 mg, a vitamin B2 content of at least 0.25 mg and a protein content of at least 4.0 g, per 100 kcal of the composition. Preferably it has a protein content of at least 5.0 g, a vitamin B6 content of at least 0.30 mg, a biotin content of at least 1.0 .mu.g, a vitamin B12 content of at least 0.20 .mu.g, a folic acid content of at least 20 .mu.g, a .beta.-carotene content of at least 100 .mu.g and a vitamin C content of at least 10 mg. Medium-chain fatty acid oils preferably constitute 35% by weight of the fats of the fat source, per 100 kcal of the composition. The preferred composition viscosity is 6-18 mPas (25.degree. C.)

pressure ulcer/albumin

Fragment of TNF-.alpha. for promoting wound healing

Total enteral nutritious composition

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