Not-celiac Wheat Sensitivity (NCWS)

Familial Mediterranean Fever (FMF)

Wheat flour will be administered once daily for 7 days

Wheat flour

Placebo Comparator

Department of Internal Medicine, Giovanni Paolo II Hospital of Sciacca

Department of Internal Medicine, University Hospital of Palermo

Gluten-related Disorders in Familial Mediterranean Fever Patients

Gluten-related Disorders in Patients Affected With Familial Mediterranean Fever

Fibromyalgia symptoms of patients, evaluated by the International Severity Scoring System for Familial Mediterranean Fever (ISSF), will be scored before and after 1 week of wheat (or placebo) ingestion

Gastrointestinal symptoms of patients, evaluated by the Gastrointestinal Symptom Rating Scale (GSRS), will be scored before and after 1 week of wheat (or placebo) ingestion

There will be evaluated some leukocytes cell surface antigens expression, i.e. CD45, CD56, CD117, NKp44, CD3, CD19, and CD14, from peripheral blood mononuclear cells and rectal mucosal lymphocytes before and after 1 week of wheat (or placebo) ingestion

There will be evaluated some cytokines production, i.e. IFN-γ, TNF-α, IL-22, IL-17, and T-bet, from peripheral blood mononuclear cells and rectal mucosal lymphocytes before and after 1 week of wheat (or placebo) ingestion

Pasquale Mansueto

Clinical Professor

University of Palermo

wheat flour is administered blindly versus placebo for 15 days

placebo will be administered blindly versus wheat flour for 15 days

Not-celiac Wheat Sensitivity

wheat flour is administered three times per day for 15 days

wheat flour

Xylose will be administered three times per day for 15 days

Xylose

Internal Medicine, "Giovanni Paolo II" Hospital

Internal Medicine, University Hospital

Bio-markers of Not-celiac Wheat Sensitivity

Not-celiac Wheat Sensitivity (NCWS) in Patients With Irritable Bowel Syndrome. Randomized Double-Blind Placebo-Controlled Trial (Wheat vs Placebo) for Bio-markers Identification of NCWS and Understanding Its Pathogenetic Mechanisms.

Symptoms/signs evaluation, before and after the challenge: total score before and after 2 weeks of wheat (or placebo) ingestion

Bio-Markers to diagnose GS and understand its pathogenesis

thyroiditis/průjem

Gluten-related Disorders in Familial Mediterranean Fever Patients

Bio-markers of Not-celiac Wheat Sensitivity

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