Ivermectin 200 mcg/kg once orally on empty stomach plus Nitazoxanide 500 mg twice daily orally with meal for 6 days

COVID-19

Ivermectin plus Nitazoxanide

Standard Care

Ivermectin and Nitazoxanide Combination Therapy for COVID-19

Clinical Trial Evaluating Safety and Efficacy of Ivermectin and Nitazoxanide Combination as Adjuvant Therapy in COVID-19 Newly Diagnosed Egyptian Patients: A Tanta University Hope

improved breaths per minute for the patients

Serum iron in microgram/dL of the patients

Serum ferritinin microgram/L of the patients

International normalized ratio "INR" for prothrombin time of 2

CBC for lymphocyte count in cells/microliter

Mortality rate [number of dead patients/total number of treated patients]

Prof. Dr. Kamal Mohammed Okasha

Vice-President of Postgraduate Studies and Research Affairs

Tanta University

This study will be a double blind randomized controlled parallel study

Autologous stem cells will be injected after conditioning

Allogeneic stem cells will be injected after conditioning

Autologous stem cells will be injected after conditioning
Autologous hematopoietic stem cell transplantation: Autologous hematopoietic stem cells will be injected after conditioning

Autologous Hematopoietic Stem Cell Transplantation

Allogeneic stem cells will be injected after conditioning
Allogeneic stem cell transplantation: Allogeneic stem cells will be injected after conditioning

Allogeneic Stem Cell Transplantation

Total

Sex: Female, Male

Region of Enrollment

Daily assessment will be made with regards to toxicity by one of the protocol investigators.National Cancer Institute Common Toxicity Criteria will be used to grade all non-hematologic toxicities. Toxicity grades as follows: 1 = Mild; 2 = Moderate; 3 = Severe and undesirable; 4 = life threatening or disabling ; 5 = Death

Presence of Toxicity

Survival

Worsening symptoms, pulmonary function studies, cardiac function and arrhythmia including EKG assessments, and neurological symptoms.

Time to Disease Progression

Overall Study

Dr Richard Burt, Chief, Division of Immunotherapy, Department of Medicine

Sarcoidosis

Autologous hematopoietic stem cells will be injected after conditioning

Autologous hematopoietic stem cell transplantation

Allogeneic stem cell transplantation

Northwestern University, Feinberg School of Medicine

Hematopoietic Stem Cell Support in Patients With Refractory Sarcoidosis

Hematopoietic Stem Cell Transplant in Patients With Refractory Sarcoidosis: A Phase I/II Trial

Richard Burt, MD

Northwestern University

Autologous Stem Cell Transplant will be performed on eligible patients

Allogeneic Stem Cell Transplant will be performed on eligible patients

Autologous Stem Cell Transplant will be performed on eligible patients
Autologous Stem Cell Transplant: Autologous Hematopoietic Stem Cell Transplant will be performed after conditioning

Autologous Stem Cell Transplant

Allogeneic Stem Cell Transplant will be performed on eligible patients
Allogeneic Stem Cell Transplant: Allogeneic Stem Cell Transplant will be performed after conditioning

Allogeneic Stem Cell Transplant

Dr Richard Burt

Vasculitis

Autologous Hematopoietic Stem Cell Transplant will be performed after conditioning

Allogeneic Stem Cell Transplant will be performed after conditioning

Cyclophosphamide

A rabbit polyclonal antibody to lymphocyte

ATG (rabbit)

G-CSF

Humanized monoclonal antibody against CD52 antigen

Campath-1h

Fludarabine

Tacrolimus

Mesna is a drug used to protect the bladder from the effects of the chemotherapy drugs

Mesna

Hematopoietic Stem Cell Support in Vasculitis

High Dose Immune Suppression With Hematopoietic Stem Cell Support in Refractory Vasculitis, Necrotizing Vasculitis, Neurovascular Behcet's Disease, and Sjogren's Syndrome

viremia/zvracení

Ivermectin and Nitazoxanide Combination Therapy for COVID-19

Hematopoietic Stem Cell Support in Patients With Refractory Sarcoidosis

Hematopoietic Stem Cell Support in Vasculitis

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