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The Effects of Rhus Coriaria L. on Serum Lipid Levels of Patients With Hyperlipidemia

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StatusAfsluttet
Sponsorer
Shiraz University of Medical Sciences

Nøgleord

Abstrakt

Coronary heart disease and stroke are two main causes of human deaths and is directly related to increased levels of plasma lipids.High total cholesterol and low high density lipoprotein cholesterol concentrations are often associated with endothelium dysfunction and inflammation, which can be followed by atherosclerosis.
Rhus coriaria L. (Rhus) with the public name of "Somagh" is a plant species in the anacardiaceae family that is used as a food supplement, spice in Middle East region (Iran, Turkey and Arabic countries).
In a double blind randomized placebo-controlled clinical trial, the investigators want to evaluate the effects of Somagh (Rhus coriaria L.) on serum lipid levels of patients with hyperlipidemia.

Beskrivelse

Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrhetic, antiseptic, anorexic and antihypergylcemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.Moreover, the hypocholesterolemic action of dietary polyphenols has been reported. The hypocholesterolemic effect of Rhus fruit powder and its components have been reported previously in rabbits and mice.

Datoer

Sidst bekræftet: 05/31/2016
Først indsendt: 11/09/2014
Anslået tilmelding indsendt: 11/16/2014
Først indsendt: 11/19/2014
Sidste opdatering indsendt: 06/03/2016
Sidste opdatering indsendt: 06/06/2016
Faktisk startdato for undersøgelsen: 11/30/2014
Anslået primær afslutningsdato: 03/31/2015
Anslået afslutningsdato for undersøgelsen: 04/30/2015

Tilstand eller sygdom

Hyperlipidemias

Intervention / behandling

Drug: Rhus

Drug: Placebo

Fase

-

Armgrupper

ArmIntervention / behandling
Experimental: Rhus
500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks
Drug: Rhus
500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks
Placebo Comparator: Placebo
Placebo capsule: 1 capsule twice daily for 6 weeks
Drug: Placebo
Placebo capsule: 1 capsule twice daily for 6 weeks

Kriterier for støtteberettigelse

Alder berettiget til undersøgelse 20 Years Til 20 Years
Køn, der er berettiget til undersøgelseAll
Accepterer sunde frivilligeJa
Kriterier

Inclusion Criteria:

- Age: 20-65 years

- Serum triglyceride >150mg/dl AND/OR total cholesterol >= 240mg/dl

Exclusion Criteria:

- Serum triglyceride > 500 mg/dl

- Serum LDL-cholesterol at level which need drug treatment according to the patient risk categories (NCEP-ATP III)

- Diabetes mellitus

- Hypo. or hyperthyroidism

- Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure

- Use of drugs: OCPs, lipid lowering agents, thiazides

- Pregnancy

- Alcoholism

- History of allergic reaction to Somagh

Resultat

Primære resultatforanstaltninger

1. Serum total cholesterol level [6 weeks]

2. Serum triglyceride level [6 weeks]

3. Serum HDL-cholesterol level [6 weeks]

Sekundære resultatforanstaltninger

1. Serum LDL-cholesterol level [6 weeks]

2. Fasting Blood Sugar (FBS) [6 weeks]

3. Serum creatinin level [6 weeks]

4. Serum ALT level [6 weeks]

5. Serum AST level [6 weeks]

6. Serum alkaline phosphatase level [6 weeks]

7. Number of patients with adverse events [10 weeks]

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