The Effects of Rhus Coriaria L. on Serum Lipid Levels of Patients With Hyperlipidemia
Nøgleord
Abstrakt
Beskrivelse
Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrhetic, antiseptic, anorexic and antihypergylcemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.Moreover, the hypocholesterolemic action of dietary polyphenols has been reported. The hypocholesterolemic effect of Rhus fruit powder and its components have been reported previously in rabbits and mice.
Datoer
Sidst bekræftet: | 05/31/2016 |
Først indsendt: | 11/09/2014 |
Anslået tilmelding indsendt: | 11/16/2014 |
Først indsendt: | 11/19/2014 |
Sidste opdatering indsendt: | 06/03/2016 |
Sidste opdatering indsendt: | 06/06/2016 |
Faktisk startdato for undersøgelsen: | 11/30/2014 |
Anslået primær afslutningsdato: | 03/31/2015 |
Anslået afslutningsdato for undersøgelsen: | 04/30/2015 |
Tilstand eller sygdom
Intervention / behandling
Drug: Rhus
Drug: Placebo
Fase
Armgrupper
Arm | Intervention / behandling |
---|---|
Experimental: Rhus 500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks | Drug: Rhus 500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks |
Placebo Comparator: Placebo Placebo capsule: 1 capsule twice daily for 6 weeks | Drug: Placebo Placebo capsule: 1 capsule twice daily for 6 weeks |
Kriterier for støtteberettigelse
Alder berettiget til undersøgelse | 20 Years Til 20 Years |
Køn, der er berettiget til undersøgelse | All |
Accepterer sunde frivillige | Ja |
Kriterier | Inclusion Criteria: - Age: 20-65 years - Serum triglyceride >150mg/dl AND/OR total cholesterol >= 240mg/dl Exclusion Criteria: - Serum triglyceride > 500 mg/dl - Serum LDL-cholesterol at level which need drug treatment according to the patient risk categories (NCEP-ATP III) - Diabetes mellitus - Hypo. or hyperthyroidism - Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure - Use of drugs: OCPs, lipid lowering agents, thiazides - Pregnancy - Alcoholism - History of allergic reaction to Somagh |
Resultat
Primære resultatforanstaltninger
1. Serum total cholesterol level [6 weeks]
2. Serum triglyceride level [6 weeks]
3. Serum HDL-cholesterol level [6 weeks]
Sekundære resultatforanstaltninger
1. Serum LDL-cholesterol level [6 weeks]
2. Fasting Blood Sugar (FBS) [6 weeks]
3. Serum creatinin level [6 weeks]
4. Serum ALT level [6 weeks]
5. Serum AST level [6 weeks]
6. Serum alkaline phosphatase level [6 weeks]
7. Number of patients with adverse events [10 weeks]