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Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery 2018-Aug

ACTIVITY OF ORBIGNYA PHALERATA AND EUTERPE EDULES IN THE PREVENTION AND TREATMENT OF PEPTIC ULCER IN RATS.

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Orlando Jorge Martins Torres
Orlando José Dos Santos
Roberto Soares de Moura
Humberto Oliveira Serra
Vanisse Portela Ramos
Syomara Pereira da Costa Melo
Carlos Manoel Bulcão Loureiro

Nøgleord

Abstrakt

BACKGROUND

Peptic ulcer is considered a public health problem associated with loss of quality of life. Does not exist optimal therapeutic regimen. The search for alternative treatments using foods or plants that may assist in gastric protection may become marked in this population because of their easy access and low cost.

OBJECTIVE

To study the antiulcerogenic activity of extracts of Orbignya phalerata (babaçu) and Euterpe edules (juçara) in Wistar rats after induction of peptic ulcer, compared with Omeprazole.

METHODS

Forty Wistar rats were distributed into four groups: group I, II, III, IV (10 rats each) subjected to extract of Orbignya phalerata, Euterpe edules, Omeprazole and ethanol, respectively. Each group of 10 rats was divided into subgroups of five for prophylaxis and therapeutic study.

RESULTS

The pre-treatment with juçara extract has provided a significant protection against peptic ulcer induced by ethanol. In the prophylactic subgroup, Omeprazole resulted in protection. In addition to protection against peptic ulcer, inflammation and neocapillarization were also variables with a statistical significance in the prophylaxis subgroups using omeprazole and juçara. In the therapeutic subgroup, omeprazole, juçara and babaçu were statistically different as for protection against the presence of inflammation and the healing of ulcers.

CONCLUSIONS

The extracts of juçara and babaçu behaved as the omeprazole, evidencing the therapeutic activity of these extracts.

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