Danish
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
Chinese Journal of Oncology 1997-Sep

[Effect of ascorbate on the permeation and photosensitizing activity of hematoporphyrin derivative (HPD) in tumor].

Kun registrerede brugere kan oversætte artikler
Log ind / Tilmeld
Linket gemmes på udklipsholderen
Y Chen
C Li
Y Liu

Nøgleord

Abstrakt

OBJECTIVE

To determine the depth of permeation and concentration of HPD in tumor tissue which had been immersed in HPD in the presence and absence of ascorbic acid, and to examine its photosensitizing effect.

METHODS

Solid S-180 sarcoma of 1 cm3 in size was excised from tumor-bearing mice and immersed in HPD (PsD-007) 1 mg/ml normal saline (group I), or HPD (PsD-007) 1 mg/ml plus ascorbic acid 20 mg/ml normal saline (group II) for 1 hr. For comparison, HPD (PsD-007) 10 mg/kg was injected intravenously to mice bearing tumor of similar size and the tumor was excised 24 hr later(group III).

RESULTS

When the tumors were cross-sectioned and UV (370 nm) irradiated, red fluorescence was mainly at the periphery of tumors that had been immersed in HPD whereas the fluorescence was weaker and more evenly distributed in tumors of mice that had received HPD i.v. Similar features were observed under fluorescence microscope in frozen sections of identically treated tumors. The concentration of PsD-007 (microgram/g) and malondialdehyde (nmol/L) in the tumor homogenates was higher in tumors that had been immersed in PsD-007 plus ascorbate than in tumors immersed in PsD-007 alone. Tumors of mice that had received PsD-007 i.v. had the lowest concentration of both PsD-007 and malondialdehyde.

CONCLUSIONS

Ascorbate facilitates permeation of HPD into tumor and enhances the photo-dynamic effect of HPD.

Deltag i vores
facebook-side

Den mest komplette database med medicinske urter understøttet af videnskab

  • Arbejder på 55 sprog
  • Urtekurer, der understøttes af videnskab
  • Urtegenkendelse ved billede
  • Interaktivt GPS-kort - tag urter på stedet (kommer snart)
  • Læs videnskabelige publikationer relateret til din søgning
  • Søg medicinske urter efter deres virkninger
  • Organiser dine interesser og hold dig opdateret med nyhedsundersøgelser, kliniske forsøg og patenter

Skriv et symptom eller en sygdom, og læs om urter, der kan hjælpe, skriv en urt og se sygdomme og symptomer, den bruges mod.
* Al information er baseret på offentliggjort videnskabelig forskning

Google Play badgeApp Store badge