[Incretory function of the pancreas and carbohydrate metabolism in patients with peptic ulcer of the duodenum].

Examination of 84 patients with peptic ulcer of the duodenum demonstrated that the majority of patients had alterations in carbohydrate metabolism manifested by fasting hypoglycemia, slow increase in glucose and hyperglycemia at the 180th minute during making the glucose tolerance test. The level of immunoreactive insulin (IRI) and immunoreactive glucagon (IRG) was discovered to range within wide limits, namely from low basal secretion to hyperinsulinemia and hyperglucagonemia at the end of examination with the use of the glucose and insulin tolerance tests. During making the glucose tolerance test, the changes in IRG concentration were more demonstrable. The changes in hormone secretion were recorded if the disease lasted long and did not depend on the stage of the process. IRI and IRG secretion was determined by both the glycemia level and concentration of the hormones themselves, by their mutually correlating influence and was aimed at the maintenance of glucose homeostasis in patients presenting with peptic ulcer of the duodenum.