Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2017-Nov
Rosiglitazone is Superior to Resveratrol in Inducing the Expression of Glyceroneogenic Genes in Adipose Tissue from Obese Participants.
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Abstrakt
We compared the effects of resveratrol and rosiglitazone, alone and in combination, on indices of fatty acid re-esterification in cultured adipose tissue from obese participants (n = 17) undergoing gastric bypass. Rosiglitazone induced PDK4 and PEPCK gene expression to a greater extent than resveratrol. Co-treatment with both compounds induced PDK4 and PEPCK expression in parallel with reductions in the fatty acid to glycerol ratio. Our findings suggest beneficial effects of resveratrol and rosiglitazone co-treatment.
