Bioorganic and Medicinal Chemistry Letters 2006-Dec
Synthesis and study of anti-inflammatory activity of some novel cyclophane amides.
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Abstrakt
Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity.