Food-dependent exercise-induced anaphylaxis to soybean: Gly m 5 and Gly m 6 as causative allergen components

Food-dependent exercise-induced anaphylaxis (FDEIA) is a life-threatening but relatively rare disorder which occurs mainly in older children and young adults and manifests with symptoms of anaphylaxis upon exercise following ingestion of certain kinds of food. We herewith report 3 cases of soybean-induced FDEIA. We also highlight 2 types of soybean-induced FDEIA, one caused by storage protein components Gly m 5 and Gly m 6 and the other caused by pollen-related allergen components.

Keywords: Ara h 1, Arachis hypogaea 1; Ara h 2, Arachis hypogaea 2; Ara h 3, Arachis hypogaea 3; Component; DAB, Diamino Benzidine; FDEIA; FDEIA, food-dependent exercise induced anaphylaxis; Gly m 4, Glycine max 4; Gly m 5; Gly m 5, Glycine max 5; Gly m 6; Gly m 6, Glycine max 6; ISU, ISAC Standardized Units; JCP, Japanese cedar pollen; Jug r 1, Juglans regia 1; PTP, Prick to Prick test; SAR, seasonal allergic rhinitis; SDS-PAGE, Sodium Dodecyl Sulfate Poly-Acrylamide Gel Electrophoresis; SPT, Skin Prick Test; Soybean.