Effect of Drugs

Safety Issues

Remifemin 0.2g po bid*12 weeks at the beginning of the LHRH-a treatment

Remifemin

Zhejiang Cancer Hospital

Remifemin Preventing the Climacteric Symptoms in Breast Cancer

The Effect of Remifemin in Preventing the Climacteric Symptoms Caused by LHRH-a Treatment in Breast Cancer: a Randomized II-stage Clinic Research

Scoring according to Kupperman item scale (Total: 0-48, the score higher the symptoms are severer) which includes of hot flash, sweat, insomnia, anxious, depressed, vertigo, fatigue, arthralgia, headache, palpitate (each item has a weighting coefficient according to four grade scores: no symptom *0, sometimes *1, always *2, influent life *3).

The other group will have 30 patients receiving tamoxifen 20 mg orally daily or exemestane (aromatase inhibitor) 25 mg orally once daily after a meal and will start with 2 tablets per day of dry extract of Cimicifuga racemosa.
Each tablet contains 20 mg of dry extract of Cimicifuga racemosa standardized between 1 mg and 1.25 mg of triterpene glycosides expressed in 26-deoxyactein. Will be guided 1 tablet 12/12 hours for 6 months.
WHOQOL questionnaire (The World Health Organization Quality of life)application for evaluation at the first visit, 3-month and 6-month follow-up.
FSFI questionnaire application for evaluation of sexual function at the first visit, 3-month and 6-month follow-up.

Control group will have 30 patients receiving tamoxifen 20 mg orally daily or exemestane (aromatase inhibitor) 25 mg orally once daily after a meal . They will be followed for 6 months and answer Kupperman scale, WHOQOL questionnaire and FSFI questionnaire at the first visit, 3-month and 6-month follow-up.
WHOQOL questionnaire (The World Health Organization Quality of life)application for evaluation at the first visit, 3-month and 6-month follow-up.
FSFI questionnaire application for evaluation of sexual function at the first visit, 3-month and 6-month follow-up.

Sexuality

WHO defines Quality of Life as individuals perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns.

WHOQOL questionnaire

FSFI questionnaire application for evaluation of sexual function at the first visit, 3-month and 6-month follow-up.

FSFI questionnaire

Kupperman scale is a tool to help evaluate the severity of menopausal symptoms

kupperman scale

The Cimicifuga racemosa effects on the sexuality of women with Breast cancer

Cimicifuga racemosa

The Cimicifuga racemosa effects on the sexuality of women with Breast cancer using tamoxifen

tamoxifen

The Cimicifuga racemosa effects on the sexuality of women with Breast cancer using aromatase inhibitor.

actaea/kræft

Remifemin Preventing the Climacteric Symptoms in Breast Cancer

Breast Cancer, Sexuality and Black Cohosh

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