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Side 1 fra 933 resultater
Yellow fever virus NS2B-NS3 protease: charged-to-alanine mutagenesis and deletion analysis define regions important for protease complex formation and function.
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Charged-to-alanine substitutions and deletions within the yellow fever virus NS2B-NS3(181) protease were analyzed for effects on protease function. During cell-free translation of NS2B-3(181) polyproteins, mutations at three charge clusters markedly impaired cis cleavage activity: a single
Yellow fever virus NS2B-NS3 protease: characterization of charged-to-alanine mutant and revertant viruses and analysis of polyprotein-cleavage activities.
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A series of 46 charged-to-alanine mutations in the yellow fever virus NS2B-NS3 protease, previously characterized in cell-free and transient cellular expression systems, was tested for their effects on virus recovery. Four distinct plaque phenotypes were observed in cell culture: parental
Hepatic serine and alanine metabolism during endotoxin-induced fever in sheep.
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Time course changes in plasma amino acid concentrations and the hepatic metabolism of serine and alanine were measured in six mature wethers during endotoxin-induced fever. In separate trials, the animals' responses to injections of saline and endotoxin were measured. The endotoxin was from
Milk fever in the cow--course of disease in relation to the serum activity of aspartate aminotransferase, alanine aminotransferase, creatine kinase and gamma-glutamyltransferase.
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The serum activity of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), creatine kinase (CK), and gamma-glutamyltransferase (GGT) was determined at the time of first and subsequent treatments in milk fever cows which responded differently to treatment, and in a number of healthy,
[Aspartate- and alanine aminotransferase activity of the blood serum in the course of rheumatic fever in children].
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[Activity of alanine aminotransferase and aspartate aminotransferase in scarlet fever and in cardiac damage in its course].
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Study on expression of plasma sCD138 in patients with hemorrhagic fever with renal syndrome.
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Until now, there is non-specific treatment, and exploring early and novel biomarkers to determine the disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS) would be of importance for clinician to take systematic and timely intervention. This study observed the expression of
Immunogenicity and Protection After Vaccination With a Modified Vaccinia Virus Ankara-Vectored Yellow Fever Vaccine in the Hamster Model.
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The highly efficacious live-attenuated 17D yellow fever (YF) vaccine is occasionally associated with rare life-threatening adverse events. Modified vaccinia virus Ankara (MVA), a non-replicating poxvirus, has been used as a vaccine platform to safely deliver various antigens. A MVA-based YF vaccine
Diagnostic splenectomy in patients with fever of unknown origin and splenomegaly.
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OBJECTIVE
To review the diagnostic significance, safety and possible risk factors of splenectomy in fever of unknown origin (FUO) with splenomegaly.
METHODS
The records of 54 patients with FUO and splenomegaly who underwent splenectomy in our hospital in the past 20 years were reviewed
Serum transaminase level changes in dengue fever and its correlation with disease severity.
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It was observed that liver enzymes are elevated in dengue fever. In this study our aims were to determine the changes in serum transaminases in dengue fever, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) and to find out the relation of transaminase level changes with the disease
Hepatotoxicity of high dose salicylate therapy in acute rheumatic fever.
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Liver function tests, including serum alanine aminotransferase (ALT) activity, serum bilirubin, alkaline phosphatase, serum proteins, blood ammonia levels and intravenous glucose utilization, were monitored in 50 children with acute rheumatic fever receiving anti-rheumatic doses of aspirin. There
Drug fever due to nomifensine treatment in patients with endogenous depression.
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Nomifensine was introduced as an effective antidepressant drug with few side effects. However, among our patients we have seen 2 typical cases of drug fever due to nomifensine. 2-4 weeks after start of nomifensine treatment, 75-150 mg/day, for recurrent endogenous depressions the patients developed
Prognostic significance of antithrombin activity in patients with crimean-congo hemorrhagic Fever.
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OBJECTIVE
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever. Disseminated intravascular coagulation (DIC) is an important complication of this disease, especially in severe and fatal cases. Antithrombin (AT) acts as an anticoagulant by inactivating thrombin, Factor IX,
[Fulminate liver failure in a 39-year-old female patient with leukocytosis, unclear fever, and arthralgic pain].
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BACKGROUND
Fulminate liver insufficiency can have many causes and is a challenge for differential diagnosis.
METHODS
A 39-year-old woman was admitted because of a nonitching macular-papular exanthema on both thighs with spreading to the trunk. In addition, the patient complained of dysphagia,
The 2011 dengue haemorrhagic fever outbreak in Lahore - an account of clinical parameters and pattern of haemorrhagic complications.
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OBJECTIVE
To describe the frequency and outcome of dengue haemorrhagic fever (DHF) cases and determine the association of clinical and laboratory parameters with haemorrhagic complications.
METHODS
A descriptive study.
METHODS
Combined Military Hospital, Lahore, from August to November
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