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Side 1 fra 806 resultater
The pharmacological action of pronase-digested egg albumin upon cerebral hypoxia.
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The purification of a substance which protects mitochondrial activity against its decay in association with various cerebral pathologies, and the effect of this substance in vitro and in vivo have been mentioned. Defatted egg albumin was hydrolyzed with pronase, and diafiltrated through mesh, to
Albumin overload induces expression of hypoxia-inducible factor 1α and its target genes in HK-2 human renal proximal tubular cell line.
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The aim of this study was to investigate the effect of human serum albumin (HSA) overload on the expression of the transcription factor hypoxia-inducible factor-1α (HIF-1α) in human renal proximal tubular cell line HK-2. First, the cell viability and cytotoxic activity were examined to assess the
Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide.
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Plasma immunoreactive atrial natriuretic peptide (irANP) and blood-to-tissue clearance of 131I-labeled rat serum albumin (CRSA) were examined in anesthetized rats during hypoxic ventilation (n = 5-7/group). Hypoxia (10 min) increased irANP from 211 +/- 29 (room air) to 229 +/- 28 (15% O2, not
Transmural [125I]albumin concentration in the rabbit aorta during acute hypoxia.
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We have quantified the concentration profile of 125I-labeled rabbit albumin in the avascular intima and media of the rabbit descending thoracic aorta following intravenous injection under control and acute hypoxic conditions in vivo. Our purpose was to determine if alterations occurred in the
Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells.
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Proteinuria is closely associated with the progression of chronic kidney diseases (CKD) by producing renal tubulointerstitial fibrosis. Over-activation of hypoxia inducible factor (HIF)-1α has been implicated in the progression of CKD. The present study tested the hypothesis that HIF-1α mediates
Hypoxia and exercise increase the transpulmonary passage of 99mTc-labeled albumin particles in humans.
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Intrapulmonary arteriovenous anastomoses (IPAVs) are large diameter connections that allow blood to bypass the lung capillaries and may provide a route for right-to-left embolus transmission. These anastomoses are recruited by exercise and catecholamines and hypoxia. Yet, whether IPAVs are recruited
Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element pathway.
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Reduction of vascular endothelial growth factor (VEGF) expression plays a crucial role in chronic kidney disease (CKD). In order to clarify a cause of VEGF suppression in CKD, we examined an interaction between proteinuria and VEGF. Rat proximal tubular cells were subjected to hypoxia with or
Albuminuria and overall capillary permeability of albumin in acute altitude hypoxia.
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The mechanism of proteinuria at high altitude is unclear. Renal function and urinary excretion rate of albumin (Ualb) at rest and during submaximal exercise and transcapillary escape rate of 125I-labeled albumin (TERalb) were investigated in 12 normal volunteers at sea level and after rapid and
Effects of anoxia on serum immunoglobulin and albumin leakage through blood-brain barrier in mouse cerebellum as revealed by cryotechniques.
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The purpose of this study was to examine time-dependent topographical changes of leaking proteins from blood vessels in the mouse cerebellum to assess the effect of normal blood circulation on the blood-brain barrier (BBB). The distribution of leaking serum proteins was immunohistochemically
Albumin-MnO2 gated hollow mesoporous silica nanosystem for modulating tumor hypoxia and synergetic therapy of cervical carcinoma.
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Currently, some approaches in cancer therapy have gradually shifted from a focus on monotherapy to combined therapy, which results in considerable superadditive therapeutic effects. Herein, bovine serum albumin integrated manganese dioxide nanoparticles (BSA-MnO2) was synthesized via a
Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition.
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Poly-S-nitrosated human serum albumin (Poly-SNO-HSA) delivered and accumulated nitric oxide (NO) in tumors and induces apoptosis. Tumor hypoxia is strongly associated with malignant progression and tumor resistance to therapy. In this study, we examined the cytotoxic effect of Poly-SNO-HSA under
Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.
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Insufficient oxygenation (hypoxia), acidic pH (acidosis), and elevated levels of reactive oxygen species (ROS), such as H2O2, are characteristic abnormalities of the tumor microenvironment (TME). These abnormalities promote tumor aggressiveness, metastasis, and resistance to therapies. To date,
Protection by albumin against ischaemia- and hypoxia-induced hepatic injury.
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In previous studies using isolated perfused rat livers, we have shown that reactive oxygen species are involved in hypoxic and ischaemic liver damage. Since albumin was shown to possess strong antioxidant properties we now investigated the capacity of albumin to prevent ischaemic and hypoxic damage
The indicator of hypoxia in acute leukemia: Ischemia-modified albumin.
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BACKGROUND
Hypoxia plays an important role in the development and progression of hematologic malignancies.
OBJECTIVE
This study was intended to investigate the effectiveness of ischemia-modified albumin (IMA) for demonstrating hypoxia in patients with acute leukemia.
METHODS
Blood specimens were
Albumin/sulfonamide stabilized iron porphyrin metal organic framework nanocomposites: targeting tumor hypoxia by carbonic anhydrase IX inhibition and T1-T2 dual mode MRI guided photodynamic/photothermal therapy.
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Exploring a nanotheranostic agent with image guided highly efficient therapeutic properties is greatly significant for tumor screening and treatment. Herein, we construct a novel nanoplatform, composed of low cost bovine serum albumin (BSA), sulfonamides (SAs) and iron porphyrin nanoscale metal
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